Fabrication of biodegradable Zn-Al-Mg alloy: Mechanical properties, corrosion behavior, cytotoxicity and antibacterial activities
Fabrication of biodegradable Zn-Al-Mg alloy: Mechanical properties, corrosion behavior, cytotoxicity and antibacterial activities
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DOI：
10.1016/j.msec.2016.11.138
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发表时间：
2017-04-01
影响因子：
7.9
通讯作者：
Cho, M. H.
中科院分区：
文献类型：
--
作者：
Bakhsheshi-Rad, H. R.;Hamzah, E.;Cho, M. H.
本文研究了不同Mg含量的二元Zn-0.5Al合金和三元Zn-0.5Al- xmg合金作为生物可降解植入材料的应用。与Zn-0.5Al（单相）合金相比，Zn-0.5Al- xmg合金由α -Zn和Mg-2(Zn, Al)（11）组成，具有良好的片层结构。结果表明，三元Zn-Al- mg合金比二元Zn-Al合金具有更高的显微硬度值、抗拉强度和耐腐蚀性。随着Mg含量的增加，合金的抗拉强度和耐蚀性均有所提高。浸渍试验还表明，腐蚀速率依次为：Zn-0.5Al-0.5Mg < Zn-0.5Al-0.3Mg < Zn-0.5Al-0.1Mg < zn - 0,5al。细胞毒性试验表明，Zn-0.5Al-0.5 mg合金比Zn-0.5Al合金具有更高的MC3T3-E1细胞活力，具有良好的生物相容性。Zn-0.5Al和Zn-0.5Al- mg合金对大肠杆菌均有一定的抑菌活性，而Zn-0.5Al-0.5 mg明显抑制大肠杆菌的生长。因此，具有适当的力学性能、低腐蚀速率、良好的生物相容性和抗菌活性的Zn-0.5Al-0.5Mg合金被认为是生物降解植入材料的良好候选材料。(C) 2016 Elsevier B.V.版权所有
In this work, binary Zn-0.5Al and ternary Zn-0.5Al-xMg alloys with various Mg contents were investigated as biodegradable materials for implant applications. Compared with Zn-0.5Al (single phase), Zn-0.5Al-xMg alloys consisted of the alpha-Zn and Mg-2(Zn, Al)(11) with a fine lamellar structure. The results also revealed that ternary Zn-Al-Mg alloys presented higher micro-hardness value, tensile strength and corrosion resistance compared to the binary Zn-Al alloy. In addition, the tensile strength and corrosion resistance increased with increasing the Mg content in ternary alloys. The immersion tests also indicated that the corrosion rates in the following order Zn-0.5Al-0.5Mg < Zn-0.5Al-0.3Mg < Zn-0.5Al-0.1Mg < Zn-0,5Al. The cytotoxicity tests exhibited that the Zn-0.5Al-0.5Mg alloy presents higher viability of MC3T3-E1 cell compared to the Zn-0.5Al alloy, which suggested good biocompatibility. The antibacterial activity result of both Zn-0.5Al and Zn-0.5Al-Mg alloys against Escherichia coli presented some antibacterial activity, while the Zn-0.5Al-0.5Mg significantly prohibited the growth of Escherichia coli. Thus, Zn-0.5Al-0.5Mg alloy with appropriate mechanical properties, low corrosion rate, good biocompatibility and antibacterial activities was believed to be a good candidate as a biodegradable implant material. (C) 2016 Elsevier B.V. All rights reserved.