Investigation of the link between visceral surface rib lesions and tuberculosis in a Medieval skeletal series from England using ancient DNA.
Investigation of the link between visceral surface rib lesions and tuberculosis in a Medieval skeletal series from England using ancient DNA.
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使用古代 DNA 研究英格兰中世纪骨骼系列中内脏表面肋骨病变与结核病之间的联系。
DOI：
10.1002/ajpa.10099
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发表时间：
2002
影响因子：
2.8
通讯作者：
G. Taylor
中科院分区：
文献类型：
--
作者：
Simon Mays;E. Fysh;G. Taylor
来自英国中世纪乡村墓地的七具人类骨骼在肋骨的内脏表面显示出病变，主要是增殖性病变。为了调查这些肋骨病变是否经常与结核感染有关，这些人与一组年龄和性别匹配、没有感染骨征的对照骨骼一起，接受了旨在检测结核分枝杆菌复合体感染微生物中微量DNA的聚合酶链式反应(PCR)分析。这些结果没有提供任何证据表明内脏表面肋骨病变和研究组中结核分枝杆菌复合体DNA的存在之间有任何规律的联系。讨论了这些发现对内脏表面肋骨病变的古病理学解释的意义。
Seven human skeletons from a large assemblage from a rural English Medieval burial site show lesions, predominantly proliferative in nature, on the visceral surfaces of the ribs. In order to investigate whether these rib lesions were regularly associated with tuberculous infection, these individuals, together with a group of age- and sex-matched control skeletons without bony signs of infection, were subjected to polymerase chain reaction (PCR) assays aimed at detecting traces of DNA from infecting microorganisms of the Mycobacterium tuberculosis complex. The results provided no evidence for any regular association between visceral surface rib lesions and the presence of M. tuberculosis complex DNA in the study group. The significance of these findings for the paleopathological interpretation of visceral surface rib lesions is discussed.