Annual Research Review: Emotion processing in offspring of mothers with depression diagnoses - a systematic review of neural and physiological research.
Annual Research Review: Emotion processing in offspring of mothers with depression diagnoses - a systematic review of neural and physiological research.
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年度研究回顾：患有抑郁症的母亲的后代的情绪处理——神经和生理研究的系统回顾。
DOI：
10.1111/jcpp.13734
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kujawa,Autumn
中科院分区：
文献类型：
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作者：
Burkhouse,KatieL;Kujawa,Autumn
背景抑郁症代际传播理论强调抑郁母亲的后代情绪处理的改变是一个关键的风险机制，引发了关于导致这些改变的生物过程的问题。这项系统性年度研究综述的目的是通过生物测量，包括自主心理生理学、脑电图 (EEG)、脑磁图 (MEG)、事件相关电位 (ERP) 以及结构和功能磁共振成像 (MRI)，检查和整合母亲抑郁症诊断与后代从出生到青春期的情绪处理之间的关联研究。方法本次审查是根据 PRISMA 2020 标准进行的。 2022 年，PsycInfo 和 PubMed 进行了一项系统性检索，研究内容包括：1）通过临床或诊断访谈评估患有或不患有 DSM 定义的抑郁症的母亲，以及 2）在出生至 18 岁之间的心理生理或神经水平上评估后代情绪处理的措施。结果 64 项研究的结果表明，有抑郁史的母亲的年轻后代表现出对负面情绪的皮质边缘激活增强。与从不抑郁的母亲的后代相比，刺激、左额叶脑激活减少、ERP 和中皮质边缘对奖励线索的反应减少。此外，参与情感处理的静息态网络的激活可以区分抑郁症和非抑郁症母亲的后代。其中一些改变仅在暴露于负面环境背景或表现出当前情绪问题的抑郁母亲的青少年中才明显。此外，其中一些模式在婴儿期就可以观察到，反映了很早就出现的脆弱性。结论这项系统评价提供的证据表明，母亲抑郁症与后代多个生物分析单位的情绪处理变化有关。我们提出了情绪处理缺陷在从母亲抑郁到后代精神病理学途径中的作用的初步概念模型，并讨论了解决现有研究局限性和临床意义的未来研究途径。
BackgroundTheories of the intergenerational transmission of depression emphasize alterations in emotion processing among offspring of depressed mothers as a key risk mechanism, raising questions about biological processes contributing to these alterations. The objective of this systematic annual research review was to examine and integrate studies of the associations between maternal depression diagnoses and offspring's emotion processing from birth through adolescence across biological measures including autonomic psychophysiology, electroencephalography (EEG), magnetoencephalography (MEG), event‐related potentials (ERP), and structural and functional magnetic resonance imaging (MRI).MethodsThe review was conducted in accordance with the PRISMA 2020 standards. A systematic search was conducted in PsycInfo and PubMed in 2022 for studies that included, 1) mothers with and without DSM‐defined depressive disorders assessed via a clinical or diagnostic interview, and 2) measures of offspring emotion processing assessed at the psychophysiological or neural level between birth and 18 years of age.ResultsFindings from 64 studies indicated that young offspring of mothers with depression histories exhibit heightened corticolimbic activation to negative emotional stimuli, reduced left frontal brain activation, and reduced ERP and mesocorticolimbic responses to reward cues compared to offspring of never‐depressed mothers. Further, activation of resting‐state networks involved in affective processing differentiate offspring of depressed relative to nondepressed mothers. Some of these alterations were only apparent among youth of depressed mothers exposed to negative environmental contexts or exhibiting current emotional problems. Further, some of these patterns were observable in infancy, reflecting very early emerging vulnerabilities.ConclusionsThis systematic review provides evidence that maternal depression is associated with alterations in emotion processing across several biological units of analysis in offspring. We present a preliminary conceptual model of the role of deficient emotion processing in pathways from maternal depression to offspring psychopathology and discuss future research avenues addressing limitations of the existing research and clinical implications.