Using DNA to predict behaviour problems from preschool to adulthood.
Using DNA to predict behaviour problems from preschool to adulthood.
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使用 DNA 预测从学前到成年的行为问题。
DOI：
10.1111/jcpp.13519
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Plomin,Robert
中科院分区：
文献类型：
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作者：
Gidziela,Agnieszka;Rimfeld,Kaili;Malanchini,Margherita;Allegrini,AndreaG;McMillan,Andrew;Selzam,Saskia;Ronald,Angelica;Viding,Essi;vonStumm,Sophie;Eley,ThaliaC;Plomin,Robert
背景DNA革命的目标之一是预测问题以便预防它们。我们在这里测试了是否可以通过创建跨年龄和跨评分者的组合以及使用包括成人精神障碍和儿童行为问题的GPS的多基因评分(GPS)来改善对行为问题的预测。方法我们的样本包括来自双胞胎早期发展研究的3,065名无血缘关系的基因分型个人，他们被父母、老师和儿童自己评估多动、行为、情绪问题和同伴问题。从15项全基因组关联研究中创建的GPS分别和联合用于测试在惩罚回归模型中跨年龄(从2岁到21岁)和跨评分者的行为问题组合(一般行为问题、外部性和内在性)的预测。基于回归权重，我们创建了反映行为问题最佳预测的多性状GPS。我们使用相同的样本和测量方法将GPS预测与双胞胎遗传力进行了比较。结果行为问题的多GPS预测从观察到的性状的2%的方差增加到跨年龄和交叉评分组合的高达6%。双研究对遗传度的估计，虽然程度较小，但反映了多个GPS预测的模式，从40%增加到83%。结论使用多个GPS、跨年龄组合和交叉评分组合可以提高GPS预测行为问题的能力，尽管影响规模仍然不大，最高可达6%。我们的方法可以用于任何基因分型样本，以创建行为问题的多性状GPS预测因子，这些预测因子将比基于单一年龄、评分者或GPS的多基因分数更具预测性。
BackgroundOne goal of the DNA revolution is to predict problems in order to prevent them. We tested here if the prediction of behaviour problems from genome‐wide polygenic scores (GPS) can be improved by creating composites across ages and across raters and by using a multi‐GPS approach that includes GPS for adult psychiatric disorders as well as for childhood behaviour problems.MethodOur sample included 3,065 genotyped unrelated individuals from the Twins Early Development Study who were assessed longitudinally for hyperactivity, conduct, emotional problems, and peer problems as rated by parents, teachers, and children themselves. GPS created from 15 genome‐wide association studies were used separately and jointly to test the prediction of behaviour problems composites (general behaviour problems, externalising, and internalising) across ages (from age 2 to 21) and across raters in penalised regression models. Based on the regression weights, we created multi‐trait GPS reflecting the best prediction of behaviour problems. We compared GPS prediction to twin heritability using the same sample and measures.ResultsMulti‐GPS prediction of behaviour problems increased from <2% of the variance for observed traits to up to 6% for cross‐age and cross‐rater composites. Twin study estimates of heritability, although to a lesser extent, mirrored patterns of multi‐GPS prediction as they increased from <40% to 83%.ConclusionsThe ability of GPS to predict behaviour problems can be improved by using multiple GPS, cross‐age composites and cross‐rater composites, although the effect sizes remain modest, up to 6%. Our approach can be used in any genotyped sample to create multi‐trait GPS predictors of behaviour problems that will be more predictive than polygenic scores based on a single age, rater, or GPS.