[Chemotherapy of malignant brain tumor by a water-soluble anti-tumor nitrosourea, ACNU (author's transl)].
[Chemotherapy of malignant brain tumor by a water-soluble anti-tumor nitrosourea, ACNU (author's transl)].
复制标题
[水溶性抗肿瘤亚硝基脲，ACNU（作者翻译）对恶性脑肿瘤的化疗]。
DOI：
10.2176/nmc.19.1157
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发表时间：
1979
影响因子：
1.9
通讯作者：
R. Katakura
中科院分区：
文献类型：
--
作者：
Teruaki Mori;K. Mineura;R. Katakura
以ACNU[1-（4-氨基-2-甲基-5-嘧啶基）甲基-3-（2-氯乙基）-3-亚硝基脲盐酸盐]治疗脑肿瘤为目的，研究ACNU对肿瘤细胞增殖的体外抑制作用、药代动力学、临床反应及毒副作用。ACNU对KS-1细胞的ED50为25 μg/ml。一般来说，胶质母细胞瘤细胞比脑膜瘤细胞对ACNU更敏感。14例脑肿瘤患者经静脉注射ACNU 100 ~ 150 mg/体后，均在5 min出现药物进入脑脊液的转变，30 min时最高值为0.59±0.13 μg/ml。对31例脑肿瘤患者进行神经学及ct检查，评价该药的治疗效果。ACNU、FT207、Tele-cobalt联合放化疗优于单纯ACNU治疗；36%的患者在我们的标准中得到“改善”，尽管55%的患者观察到ACNU的血液学毒性。
For the purpose of treatment of brain tumors with ACNU [1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride], inhibitory effects on tumor cell proliferation in vitro, pharmacokinetics, clinical responses and side effects of the drug were investigated. ED50 of ACNU for KS-1 cells was 25 μg/ml. Generally, glioblastoma cells were more sensitive to ACNU than meningioma cells. After intravenous injection of ACNU 100-150 mg/boby, in 14 patients with brain tumors, transition of the drug into cerebrospinal fluid was noticed at 5 minutes in all cases with the maximum value of 0.59±0.13 μg/ml at 30 minutes. The therapeutic effects of the drug were evaluated in 31 patients with brain tumors by neurological and CT-scan examinations. Combined chemo-radiotherapy with ACNU, FT207 and Tele-cobalt was more effective than ACNU therapy alone; 36% of the patients were “improved” in our criteria, although hematologic toxicity of ACNU was observed in 55%.