LOVD: Easy creation of a locus-specific sequence variation database using an "LSDB-in-a-Box" approach
LOVD: Easy creation of a locus-specific sequence variation database using an "LSDB-in-a-Box" approach
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DOI：
10.1002/humu.20201
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发表时间：
2005-08-01
期刊：
影响因子：
3.9
通讯作者：
Taschner, PEM
中科院分区：
文献类型：
--
作者：
Fokkema, IFAC;den Dunnen, JT;Taschner, PEM
人类基因组计划的完成启动了收集和研究个体之间所有序列变异的工作，并为之提供了基础。目前，通过基于网络的基因中心基因座特异性数据库（LSDB）最有效地提供了对关于序列变异的最新信息的直接访问。我们已经开发了莱顿开放（源）变异数据库（LOVD）软件接近“LSDB在一个盒子”的想法，轻松创建和维护一个完全基于网络的基因序列变异数据库。LOVD是平台无关的，只使用PHP和MySQL开源软件。该数据库的基本设计遵循人类基因组变异学会（HGVS）的建议，以基因为中心，模块化，重点是收集和显示DNA序列变异。只需最小的努力，LOVD平台就可以扩展临床数据。开放的设置应该通过社区编写的脚本来促进和促进功能扩展。LOVD软件可从莱顿肌营养不良页面（www.DMD.nl/LOVD/）免费获得。为了促进LOVD的使用，我们目前为策展人提供在莱顿服务器上设置LSDB的可能性。
The completion of the human genome project has initiated, as well as provided the basis for, the collection and study of all sequence variation between individuals. Direct access to up-to,date information on sequence variation is currently provided most efficiently through web based, gene,centered, locus-specific databases (LSDBs). We have developed the Leiden Open (source) Variation Database (LOVD) software approaching the "LSDB-in-a-Box" idea for the easy creation and maintenance of a fully web-based gene sequence variation database. LOVD is platform-independent and uses PHP and MySQL open source software only. The basic gene-centered and modular design of the database follows the recommendations of the Human Genome Variation Society (HGVS) and focuses on the collection and display of DNA sequence variations. With minimal effort, the LOVD platform is extendable with clinical data. The open set-up should both facilitate and promote functional extension with scripts written by the community. The LOVD software is freely available from the Leiden Muscular Dystrophy pages (www.DMD.nl/LOVD/). To promote the use of LOVD, we currently offer curators the possibility to setup an LSDB on our Leiden server.