Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats
Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats
复制标题
DOI：
10.1016/s0165-1838(98)00084-8
复制
发表时间：
1998-08-06
期刊：
影响因子：
--
通讯作者：
Kannan, H
中科院分区：
文献类型：
--
作者：
Shimokawa, A;Kunitake, T;Kannan, H
使用长期记录血压（BP）、心电图和肾交感神经活动（RSNA）的大鼠，检查戊巴比妥钠、氯醛糖和乌拉坦对交感神经活动和动脉压力感受器反射的影响。戊巴比妥钠（30 mg/kg，静脉注射）可降低血压，同时心率 (HR) 短暂降低，而 RSNA 没有变化。氯醛糖（50 mg/kg，静脉注射）也导致血压下降，但 HR 和 RSNA 没有变化，直到后来 HR 和 RSNA 增加，而乌拉坦（800 mg/kg，静脉注射）则增加血压、HR 和 RSNA。通过构建逻辑函数曲线来评估压力感受器反射功能，该逻辑函数曲线是根据静脉输注增加剂量的去氧肾上腺素和硝普钠获得的数据而编制的。戊巴比妥钠和氯醛糖的施用均降低了 HR 和 RSNA 的压力感受器反射控制增益。氨基甲酸酯还降低了 HR 压力感受器反射控制的增益，但未引起 RSNA 的变化。这些结果表明，不同的静脉注射麻醉剂以不同的定性和定量方式影响外周交感神经流出。 (C) 1998 Elsevier Science B.V. 保留所有权利。
The effects of pentobarbital sodium, chloralose, and urethane on sympathetic nerve activity and arterial baroreceptor reflex were examined using rats chronically instrumented for recordings of blood pressure (BP), electrocardiogram and renal sympathetic nerve activity (RSNA). Pentobarbital sodium (30 mg/kg, i.v.) produced a decrease in BP with a transient decrease in heart rate (HR) and no change in RSNA. Chloralose (50 mg/kg, i.v.) also caused a decrease in BP and no change in HR and RSNA until a later increase in HR and RSNA, while urethane (800 mg/kg, i.v.) increased BP, HR, and RSNA. Baroreceptor reflex function was assessed by constructing a logistic function curve compiled from data obtained by intravenous infusion in increasing doses of phenylephrine and sodium nitroprusside. Both pentobarbital sodium and chloralose administration decreased the gain of baroreceptor reflex control of both HR and RSNA. Urethane also decreased the gain of baroreceptor reflex control of HR but elicited no change in that of RSNA. These results suggest that different intravenously administered anesthetics affect the peripheral sympathetic outflows in qualitatively and quantitatively different manners. (C) 1998 Elsevier Science B.V. All rights reserved.