Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake
Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake
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DOI：
10.1152/japplphysiol.01231.2007
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发表时间：
2008-05-01
影响因子：
3.3
通讯作者：
Rangwala, Shamina M.
中科院分区：
文献类型：
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作者：
Calvo, Jennifer A.;Daniels, Thomas G.;Rangwala, Shamina M.
PGC-1α是线粒体发生的关键调节因子，在包括耐力、耐力和短跑训练在内的多种运动方案中，对PGC-1α的诱导作用已得到证实。我们想要确定增加肌肉中PGC-1α的表达是否足以改善在活体运动中的表现。我们证明了肌肉特异性的PGC-1α的表达改善了在自愿运动和强迫运动挑战中的表现。此外，PGC-1α转基因小鼠在峰值摄氧量运动测试中表现出增强的表现，表现出峰值氧化能力或全身摄氧量的增加。线粒体基因表达、线粒体DNA和线粒体酶活性的增加表明，线粒体功能的增强支持了这种在多种运动范例中执行能力的增强。因此，本研究表明，在活体肌肉中上调PGC-1α足以极大地改善各种运动模式下的运动成绩，并增加峰值摄氧量。
The induction of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), a key regulator of mitochondriogenesis, is well-established under multiple physical exercise regimens, including, endurance, resistance, and sprint training. We wanted to determine if increased expression of PGC-1 alpha in muscle is sufficient to improve performance during exercise in vivo. We demonstrate that muscle-specific expression of PGC-1 alpha improves the performance during voluntary as well as forced exercise challenges. Additionally, PGC-1 alpha transgenic mice exhibit an enhanced performance during a peak oxygen uptake exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake. This increased ability to perform in multiple exercise paradigms is supported by enhanced mitochondrial function as suggested by increased mitochondrial gene expression, mitochondrial DNA, and mitochondrial enzyme activity. Thus this study demonstrates that upregulation of PGC-1 alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake.