MAMMALIAN LUNG DEVELOPMENT - INTERACTIONS IN FORMATION AND MORPHOGENESIS OF TRACHEAL BUDS
MAMMALIAN LUNG DEVELOPMENT - INTERACTIONS IN FORMATION AND MORPHOGENESIS OF TRACHEAL BUDS
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DOI：
10.1002/jez.1401750405
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发表时间：
1970-01-01
影响因子：
--
通讯作者：
WESSELLS, NK
中科院分区：
文献类型：
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作者：
WESSELLS, NK
中胚层存在于发育早期的肺中，有两种类型：一种是支气管，它能促使气管上皮形成支气管芽；另一种是气管，它抑制支气管的形态发生。后一过程与上皮表面附近高度有序的胶原鞘和中胚层细胞的存在有关。相比之下，支气管中胚层缺乏这种规则排列的成分。非特定的中胚层可以在气管上最初形成多余的芽，但这种芽永远不会分枝。如果要发生后一种形态发生过程，则需要支气管中胚层。胸腺嘧啶标记实验不能提供证据表明不同的有丝分裂活动导致最初的芽形成。
Mesoderm present in early developing lung is of two sorts: bronchial, which can evoke formation of bronchial buds from tracheal epithelium; and tracheal, which inhibits bronchial morphogenesis. The latter process correlates with the presence of highly ordered sheaths of collagen and mesoderm cells near the epithelial surface. In contrast, bronchial mesoderm lacks such regularly arrayed components. Initial formation of supernumerary buds on the trachea can be evoked by nonspecific mesoderms, but such buds never branch. Bronchial mesoderm is required if the latter morphogenetic process is to occur.Thymidine labeling experiments fail to provide evidence that differential mitotic activity leads to initial bud formation.