Immune response after a single intravenous peramivir administration in children with influenza
Immune response after a single intravenous peramivir administration in children with influenza
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DOI：
10.3851/imp3222
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发表时间：
2018-01-01
影响因子：
1.2
通讯作者：
Hosoya, Mitsuaki
中科院分区：
文献类型：
--
作者：
Sato, Masatoki;Hashimoto, Koichi;Hosoya, Mitsuaki
背景：日本批准用于儿童流感感染的静脉注射帕拉米韦后的免疫应答尚不清楚。方法：分别对17例和8例甲型和乙型流感住院患儿治疗前后的病毒载量和血清细胞因子水平进行动态分析。此外，还测定了血凝抑制(HI)效价。结果：甲型流感患儿经帕拉米韦治疗后血清IL-6水平明显下降，而乙型流感患儿血清IL-6水平在治疗后第1天下降，第2天升高。甲型流感和乙型流感患儿0~2天血清IL-6水平与病毒载量动态相似。甲型流感患儿治疗后血清IL-8水平逐渐下降，乙型流感患儿血清IL-8水平在1~2天升高。相反，随着时间的推移，血清IL-10水平逐渐下降。血清干扰素-γ和粒-巨噬细胞集落刺激因子水平一直维持在较低水平直到第5天。
Background: Immune response after intravenous peramivir administration, which is approved for children with influenza infection in Japan, is unclear.Methods: Kinetics of viral load and serum cytokine levels before and after peramivir therapy were analysed in 17 and 8 hospitalized children infected with influenza A and B, respectively. Additionally, haemagglutination inhibition (HI) titre was measured. The first day of hospital admission was defined as day 0.Results: Serum interleukin (IL)-6 levels in influenza-A-infected children significantly decreased after peramivir administration, unlike in those with influenza B where a decrease on day 1 was followed by an increase on day 2. Serum IL-6 kinetics were similar to viral load kineticsin both influenza-A- and B-infected children between days 0 and 2. Serum IL-8 levels gradually decreased after peramivir therapy in influenza-A-infected children but increased between days 1 and 2 in influenza-B-infected children. Conversely, serum IL-10 levels gradually decreased over time. Serum interferon-gamma and granulocyte macrophage colony-stimulating factor levels remained low until day 5. Day 0-4 serum HI titres were