Expanding role of ubiquitination in NF-κB signaling.
Expanding role of ubiquitination in NF-κB signaling.
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作者：
最为人所知的是其在靶向蛋白质降解到蛋白酶体中的作用，泛素修饰也已成为通过蛋白酶体非依赖性机制调节细胞信号传导的重要机制。泛素作为一种多功能的信号标签的作用在NF-κB通路中得到了典型的说明，NF-κB通路调节多种生理和病理过程以响应不同的刺激。本文综述了泛素化在NF-κB信号级联反应不同步骤中的作用，重点介绍了在不同途径中汇聚于NF-κB的多聚泛素链激活蛋白激酶机制的最新进展。
Best known for its role in targeting protein degradation to the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.
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影响因子：
32.4
作者：
Bertrand, Mathieu J. M.;Doiron, Karine;Saleh, Maya
通讯作者：
Saleh, Maya
影响因子：
7.7
作者：
Friedman, Constantin S.;O'Donnell, Marie Anne;Ting, Adrian T.
通讯作者：
Ting, Adrian T.
DOI：
10.5483/bmbrep.2007.40.3.341
发表时间：
2007-05-31
期刊：
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
影响因子：
--
作者：
Chung, Young-Hwa;Jhun, Byung Hak;Lee, Sang Jun
通讯作者：
Lee, Sang Jun
影响因子：
16
作者：
Bertrand, Mathieu J. M.;Milutinovic, Snezana;Barker, Philip A.
通讯作者：
Barker, Philip A.
影响因子：
64.8
作者：
Brummelkamp, TR;Nijman, SMB;Bernards, R
通讯作者：
Bernards, R