Extracellular matrix-based biomaterials for cardiac regeneration and repair
Extracellular matrix-based biomaterials for cardiac regeneration and repair
复制标题
用于心脏再生和修复的细胞外基质生物材料
DOI：
10.1007/s10741-020-09953-9
复制
发表时间：
2020-04-18
影响因子：
4.6
通讯作者：
Nie, Yu
中科院分区：
文献类型：
--
作者：
Li, Haotong;Bao, Minghui;Nie, Yu
缺血性心脏病的范围，包括急性心肌梗死到心力衰竭，是全世界死亡的主要原因。尽管在心血管诊断和治疗方面取得了广泛进展，但该疾病的患病率仍在继续增加。心脏再生在治疗心力衰竭方面具有广阔的前景。近年来，细胞外基质（extracellular matrix， ECM）在心脏损伤后的再生和修复中发挥着重要作用。也有证据表明，ECM可以直接用作促进心肌细胞增殖和心脏再生的药物。越来越多的证据支持，应用ECM生物材料维持心脏功能恢复是未来将心脏再生医学概念应用于临床实践的重要途径。本文将介绍ECM在心脏再生中的重要作用，并对ECM生物材料促进心脏修复的方法进行综述。
The spectrum of ischemic heart diseases, encompassing acute myocardial infarction to heart failure, represents the leading cause of death worldwide. Although extensive progress in cardiovascular diagnoses and therapy has been made, the prevalence of the disease continues to increase. Cardiac regeneration has a promising perspective for the therapy of heart failure. Recently, extracellular matrix (ECM) has been shown to play an important role in cardiac regeneration and repair after cardiac injury. There is also evidence that the ECM could be directly used as a drug to promote cardiomyocyte proliferation and cardiac regeneration. Increasing evidence supports that applying ECM biomaterials to maintain heart function recovery is an important approach to apply the concept of cardiac regenerative medicine to clinical practice in the future. Here, we will introduce the essential role of cardiac ECM in cardiac regeneration and summarize the approaches of delivering ECM biomaterials to promote cardiac repair in this review.