Predicting the external formation of callus tissues in oblique bone fractures: idealised and clinical case studies
Predicting the external formation of callus tissues in oblique bone fractures: idealised and clinical case studies
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DOI：
10.1007/s10237-012-0468-6
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发表时间：
2013-11-01
影响因子：
3.5
通讯作者：
O'Byrne, J.
中科院分区：
文献类型：
--
作者：
Comiskey, D.;MacDonald, B. J.;O'Byrne, J.
有人提出，外部不对称形成的骨痂组织，自然形成的斜骨折可以预测计算。我们分析了两例骨折愈合的骨痂形成：理想化和特定对象的斜骨折。平面应变有限元（FE）模型的斜骨折产生的未成熟的骨痂组织所经历的压缩应变场计算由于interfragmental运动。使用优化风格算法从现象学上模拟愈伤组织的外部形成，该算法迭代地从大域中去除经历低应变的组织。两个骨折病例的愈合组织的所得模拟空间形成显示，骨痂倾向于以与斜骨折线的角度相等的角度形成。计算结果与体内发现的愈伤组织形成定性相关。因此，所提出的方法显示出作为在临床前测试中预测愈伤组织形成的手段的潜力。
It is proposed that the external asymmetric formation of callus tissues that forms naturally about an oblique bone fracture can be predicted computationally. We present an analysis of callus formation for two cases of bone fracture healing: idealised and subject-specific oblique bone fractures. Plane strain finite element (FE) models of the oblique fractures were generated to calculate the compressive strain field experienced by the immature callus tissues due to interfragmentary motion. The external formations of the calluses were phenomenologically simulated using an optimisation style algorithm that iteratively removes tissue that experiences low strains from a large domain. The resultant simulated spatial formation of the healing tissues for the two bone fracture cases showed that the calluses tended to form at an angle equivalent to the angle of the oblique fracture line. The computational results qualitatively correlated with the callus formations found in vivo. Consequently, the proposed methods show potential as a means of predicting callus formation in pre-clinical testing.