Burn Infection and Burn Sepsis
Burn Infection and Burn Sepsis
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DOI：
10.1089/sur.2020.102
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发表时间：
2020-05-04
影响因子：
2
通讯作者：
Shahrokhi, Shahriar
中科院分区：
文献类型：
--
作者：
D'Abbondanza, Josephine A.;Shahrokhi, Shahriar
背景：感染是烧伤患者最常见的并发症和死亡原因。这些患者易受感染和烧伤创面脓毒症继发于他们的生理变化。感染的诊断和管理依赖于体格检查、培养和烧伤wound.Method的病理学：我们在Google Scholar和PubMed数据库中使用检索词“烧伤脓毒症”、“烧伤感染”和“烧伤重症监护”对文章进行了电子检索。“结果：多种因素增加了烧伤患者的侵袭性感染和败血症的风险，包括潜在因素和共病、烧伤的总体表面积百分比、烧伤伤口切除的延迟和微生物毒力/细菌计数。引起烧伤伤口感染的微生物不同，这取决于受伤后的时间和位置;诊断是多因素的。最常见的病原体仍然是葡萄球菌和假单胞菌。结论：总体而言，烧伤脓毒症的认识是基于临床表现。治疗包括局部包扎、早期烧伤切除和全身抗菌治疗。过去10年来，死亡率大幅下降，但必须继续努力及时管理和预防感染。
Background: Infection is the most common complication and cause of death in patients suffering burn injuries. These patients are susceptible to infection and burn wound sepsis secondary to the alterations in their physiology. Diagnosis and management of infections rely on physical examination, cultures, and the pathology of the burn wound.Method: We performed an electronic search for articles in the Google Scholar and PubMed databases using the search terms "burn sepsis," "burn infection," and "burn critical care."Results: Multiple factors increase burn patients' risk of invasive infection and sepsis, including underlying factors and co-morbidities, the percent total body surface area of the burn, delays in burn wound excision, and microbial virulence/bacterial count. Organisms causing burn wound infection differ, depending on the time since injury and its location; and diagnosis is multi-factorial. The most common pathogens remain Staphylococcus and Pseudomonas spp.Conclusion: Overall, the recognition of burn sepsis is based on clinical findings. Treatment consists of a combination of local dressings, early burn excision, and systemic antimicrobial therapy. The mortality rate has decreased significantly over the past 10 years, but continued efforts at timely management and infection prevention are essential.