Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice
Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice
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嗅觉缺陷 Cnga2 基因敲除小鼠的焦虑和抑郁样行为
DOI：
10.1016/j.bbr.2014.08.042
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发表时间：
2014-12-15
影响因子：
2.7
通讯作者：
Wang, Jianhong
中科院分区：
文献类型：
--
作者：
Chen, Yanmei;Liu, Xiaofen;Wang, Jianhong
气味和情绪处理之间有着密切的神经解剖学联系。嗅觉功能障碍见于各种神经退行性疾病和神经精神疾病。在这里，小鼠采用环核苷酸门控通道2突变基因（Cnga2），这是嗅觉感觉神经元产生气味诱导动作电位的关键。Cnga2小鼠是先天性嗅觉障碍。采用开阔场、明暗箱、强迫游泳和y型迷宫等行为模式对成年小鼠进行实验。我们的研究发现，Cnga2小鼠比它们的宽型兄弟姐妹表现出更多的焦虑和抑郁样行为。然而，Cnga2小鼠在两次识别y迷宫中与宽型小鼠没有差异。结果表明，先天嗅觉缺陷可能调节小鼠的情绪行为。(C) 2014 Elsevier B.V.版权所有
There is a close neuroanatomical connection between odor and emotional processing. Olfactory dysfunction is found in various neurodegenerative and neuropsychiatric disorders. Here, mice take the cyclic nucleotide gated channel 2 mutant gene (Cnga2), which is critical for olfactory sensory neurons to generate odor induced action potentials were used. The Cnga2 mice were congenitally anosmic. Adult mice were tested in a series behavioral paradigm such as open field, light/dark box, forced swim test and Y-maze. Our study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings. However, Cnga2 mice showed no difference from the wide types when tested in the two-trial recognition Y-maze. The results indicate that innate olfactory deficiency might modulate emotional behaviors in mice. (C) 2014 Elsevier B.V. All rights reserved.