Association between tongue coating thickness and clinical characteristics among idiopathic membranous nephropathy patients
Association between tongue coating thickness and clinical characteristics among idiopathic membranous nephropathy patients
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DOI：
10.1016/j.jep.2015.05.008
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发表时间：
2015-08-02
影响因子：
5.4
通讯作者：
Yu DongRong
中科院分区：
文献类型：
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作者：
Lin RiYang;Yu HangYing;Yu DongRong
民族药理学相关性：舌苔诊断是中医检查人体变化的有用工具。肾脏疾病时舌苔的厚度会有所不同。然而，关于 CKD 患者临床特征与舌苔厚度之间的关联性的信息很少。 研究目的：本研究旨在确定特发性膜性肾病患者的舌苔厚度与实验室、组织学变量之间是否存在关联：一组舌苔薄，另一组舌苔厚。材料和方法：2012 年 7 月至 2014 年 3 月期间，特发性膜性肾病患者 (CKD) 1-2期）舌苔厚度评分=11，入组为薄舌苔组或厚舌苔组，来自杭州中医院。实验室变量（血红蛋白 (Hb)、白蛋白 (Alb)、eGFR、丙氨酸转移酶 (ALT)、天冬氨酸转氨酶 (AST)、甘油三酯 (TG)、总胆固醇 (TC)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、免疫球蛋白 A、G、M、补体 3、4）和肾脏组织学数据（肾小球病变；肾小管间质损伤）比较两组之间的差异。结果：12 例舌苔薄（舌苔厚度评分为 7）的特发性 MN 患者（CKD 1-2 期）和 11 例舌苔厚（舌苔厚度评分> 11）患者纳入本研究。我们发现，与薄舌苔患者相比，厚舌苔患者的TC和LDL水平显着降低，AST、ALT水平显着降低。厚、薄舌苔患者的病理病变无明显差异。结论：特发性MN患者（CKD 1-2期）舌苔厚度与脂质代谢相关。 o 2015 Elsevier Ireland Ltd. 保留所有权利。
Ethnopharmacological relevance: Tongue coating diagnosis is a useful tool to examine the changes of a human body in Chinese Medicine. Tongue coating varies in thickness in kidney disease. However, little information exists regarding the association between clinical characters and tongue coating thickness in CKD patients.Aim of the study: This study was carried out to determine whether there is an association between tongue coating thickness and laboratory, histological variables in idiopathic membranous nephropathy patients: one group with thin tongue coating, the other with thick tongue coating.Materials and methods: During July 2012-March 2014, idiopathic membranous nephropathy patients (CKD 1-2 stage) with tongue coating thickness Score = 11, were enrolled as thin tongue coating group or thick tongue coating group, from Hangzhou Hospital of TCM. Laboratory variables (Hemoglobin (Hb), albumin (Alb); eGFR; alanine transferase (ALT); aspartate aminotransferase (AST); triglyceride (TG); total cholesterone (TC); high density lipoprotein (HDL); low density lipoprotein (LDL); immunoglobin A, G, M; Complement 3, 4) and renal histological data (glomerular lesions; tubular-interstitial damage) were compared, between these two groups.Results: 12 idiopathic MN patients (CKD 1-2 stage) with thin tongue coating (tongue coating thickness score 7) and 11 with thick tongue coating (tongue coating thickness score > 11) were enrolled in our study. We found a significant lower level of TC and LDL, a significant lower level of AST, ALT in those thick tongue coating patients, compared with thin. No significant difference was observed in pathological lesion between thick and thin tongue coating patients.Conclusion: Tongue coating thickness is associated with lipid metabolism in idiopathic MN patients (CKD 1-2 stages). o 2015 Elsevier Ireland Ltd. All rights reserved.