Familial resemblance in fatness indicators.
Familial resemblance in fatness indicators.
复制标题
肥胖指标的家族相似性。
作者：
R. Savard;C. Bouchard;C. Leblanc;A. Tremblay
研究人员对来自居住在大魁北克城区的 114 个法国血统家庭的 481 名个体的肥胖家族相似性进行了研究。测量受试者的以下脂肪指标：三头肌、二头肌、肩胛下肌、髂上肌、腹部和小腿内侧皮褶。还考虑了这六个皮褶的总和以及身体脂肪百分比的预测（Durnin 和 Rahaman 1967）。根据适当的年龄和性别类别对数据进行标准化，得出 SS 分数。相关生活方式变量（能量摄入、能量消耗和社会经济地位）的影响从统计上从 SS 产生的剩余分数 (RS) 中去除，然后提交给家族分析。方差分析表明，当考虑整个核心家庭或同胞时，SS 的家庭间变异大于内部变异（P 小于或等于 0.01）；在这些情况下，类内相关性范围为 0.15 到 0.26。然而，配偶之间的 SS 肥胖指标没有显着相似性。 RS 脂肪指标基本上也发现了类似的值。此外，除了肩胛下和小腿皮褶RS之外，夫妻间的相关性并不显着。然而，对于 SS，生物学亲属之间的协变是显着的（0.16 小于或等于 r 小于或等于 0.24，P 小于或等于 0.01），并且在对生活方式变量进行统计控制后基本保持不变（0.16 小于或等于 r 小于或等于 0.40，P 小于或等于 0.01）。研究结果表明，配偶在肥胖方面没有显着的共变，而传统核心家庭的亲生亲属即使在对每日能量摄入、每日能量消耗和社会经济地位进行统计控制后也表现出显着程度的相似性，这为支持人类肥胖存在显着遗传效应的假设提供了证据。
Family resemblance in fatness has been studied in 481 individuals from 114 families of French descent living in the greater Quebec city area. Subjects were measured for the following fatness indicators: triceps, biceps, subscapular, suprailiac, abdominal and medial calf skinfolds. The sum of these six skinfolds as well as a prediction of percent body fat (Durnin and Rahaman 1967) were also considered. Data were standardized for appropriate age and sex classes yielding SS scores. The influence of relevant lifestyle variables (energy intake, energy expenditure and socioeconomic status) were statistically removed from SS yeilding residual scores (RS) that were then submitted to familial analyses. Analyses of variance indicate that there is a larger between family variation than within (P less than or equal to 0.01) for SS when considering either the whole nuclear family or sibships; in these instances, the intra-class correlation ranges from 0.15 to 0.26. There was, however, no significant resemblance among spouses for the SS fatness indicators. Similar values were essentially found for RS fatness indicators. Furthermore, husband-wife inter-class correlations were not significant with the exception of subscapular and calf skinfold RS. Covariations between biological relatives are however significant (0.16 less than or equal to r less than or equal to 0.24, P less than or equal to 0.01) for SS and remain essentially unchanged after statistical control over the lifestyle variables (0.16 less than or equal to r less than or equal to 0.40, P less than or equal to 0.01). The findings that spouses do not covary significantly in fatness, while biological relatives of traditional nuclear families exhibit a significant degree of resemblance even after statistical control over daily energy intake, daily energy expenditure and socioeconomic status provide evidence supporting the hypothesis that there is a substantial genetic effect in human fatness.