Effector memory T cells, early metastasis, and survival in colorectal cancer
Effector memory T cells, early metastasis, and survival in colorectal cancer
复制标题
DOI：
10.1056/nejmoa051424
复制
发表时间：
2005-12-22
影响因子：
158.5
通讯作者：
Galon, J
中科院分区：
文献类型：
--
作者：
Pagès, F;Berger, A;Galon, J
背景：肿瘤浸润免疫细胞在结直肠癌早期转移性侵袭中的作用尚不清楚。方法：我们研究了 959 例结直肠癌切除标本中早期转移性侵袭（静脉栓塞、淋巴管和神经周围侵犯）的病理征象。通过流式细胞术（39 个肿瘤）、低密度阵列实时聚合酶链反应测定（75 个肿瘤）和组织微阵列（415 个肿瘤）研究肿瘤内的局部免疫反应。 结果：单变量分析显示，根据早期转移性侵袭的组织学迹象的存在与否，无病生存率和总生存率存在显着差异（P
Background: The role of tumor-infiltrating immune cells in the early metastatic invasion of colorectal cancer is unknown.Methods: We studied pathological signs of early metastatic invasion (venous emboli and lymphatic and perineural invasion) in 959 specimens of resected colorectal cancer. The local immune response within the tumor was studied by flow cytometry (39 tumors), low-density-array real-time polymerase-chain-reaction assay (75 tumors), and tissue microarrays (415 tumors).Results: Univariate analysis showed significant differences in disease-free and overall survival according to the presence or absence of histologic signs of early metastatic invasion (P