1995 Flemming Lecture. DNA topology and the global control of bacterial gene expression: implications for the regulation of virulence gene expression.
1995 Flemming Lecture. DNA topology and the global control of bacterial gene expression: implications for the regulation of virulence gene expression.
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1995 年弗莱明讲座。
作者：
Charles J. Dorman
细菌细胞是相对简单的实体，具有小的单倍体基因组。尽管它们很简单，但它们有能力应对环境的突然和严重变化。这种适应性使细菌能够在广泛的生态环境中定居。当在其他生物身上或体内发现这些小生境时，细菌可能会产生一种病理状态。人们渴望深入了解细菌致病的机制，这一直是细菌环境适应研究的推动力。这些调查的结果揭示了许多致病和非致病生物共有的特征。这些能力包括感知外部环境的变化并以适当的方式做出反应的能力。这种反应经常涉及到细胞转录图谱的改变，因为几个基因的表达同时被上调或下调。这一现象意味着细胞中存在协调控制转录变化的程序。我的实验室的研究努力旨在阐明这种协调的基因调控计划的分子基础。
Bacterial cells are relatively simple entities with small, haploid genomes. Despite their simplicity, they are capable of coping with sudden and severe changes in the environment. This adaptability enables bacteria to colonize a wide range of ecological niches. When these niches are found on or within other living things, the bacteria may produce a pathological condition. The desire to obtain insights into the mechanisms by which bacteria cause disease has been a driving force in investigations of environmental adaptation by bacteria. The results of these investigations have revealed features which are common to many pathogenic and non-pathogenic organisms. These include an ability to sense changes in the external environment and to respond in an appropriate manner. This response frequently involves a change in the transcriptional profile of the cell as the expression of several genes is upor down-regulated simultaneously. This phenomenon implies that programmes exist in the cell for coordinated control of changes in transcription. The research efforts of my laboratory have been aimed at elucidating the molecular basis of this coordinated gene regulatory programme.
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DOI：
10.1016/s0021-9258(18)37625-7
发表时间：
1988-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
David E. Pettijohn
通讯作者：
David E. Pettijohn
大肠杆菌 1 型拓扑异构酶：鉴定、机制和在重组中的作用。
DOI：
10.1101/sqb.1983.047.01.088
发表时间：
1983
期刊：
Cold Spring Harbor symposia on quantitative biology
影响因子：
--
作者：
Dean,F;Krasnow,MA;Otter,R;Matzuk,MM;Spengler,SJ;Cozzarelli,NR
通讯作者：
Cozzarelli,NR
影响因子：
5.6
作者：
RAHMOUNI, AR;WELLS, RD
通讯作者：
WELLS, RD
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
DiGate,RJ;Marians,KJ
通讯作者：
Marians,KJ