Associations of Chronic Burden, Sleep Characteristics, and Metabolic Syndrome in the Coronary Artery Risk Development in Young Adults Study.
Associations of Chronic Burden, Sleep Characteristics, and Metabolic Syndrome in the Coronary Artery Risk Development in Young Adults Study.
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DOI：
10.1097/psy.0000000000001081
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发表时间：
2022-07-01
影响因子：
3.3
通讯作者：
Kershaw, Kiarri N.
中科院分区：
文献类型：
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作者：
Johnson, Dayna A.;Knutson, Kristen;Colangelo, Laura A.;Hale, Lauren;Redline, Susan;Carnethon, Mercedes;Kershaw, Kiarri N.
关键词：
慢性应激与代谢综合征（MetS）有关，但其机制尚不清楚。我们在CARDIA研究中调查了慢性负担、睡眠和代谢综合征之间的关系。慢性负担是自我报告的（2000-2001年），根据与压力源超过6个月的经验。腕关节活动记录仪测量的睡眠持续时间和睡眠效率收集了6天;睡眠持续时间，睡眠质量和白天嗜睡是自我报告的（2003-2004）。在2005-2006年的门诊访视期间测量MetS。拟合多变量logistic和考克斯比例风险模型以确定相关性。使用系数法的产品进行评估的调解睡眠。在参与者（N=606）中，平均年龄为40岁（标准差=3.6），58%为女性，43%为黑人。慢性负荷、睡眠不足（≤6小时）和代谢综合征的患病率分别为35%、43%和20.5%。高慢性负担与低慢性负担相比，与自我报告的睡眠时间较短和白天嗜睡程度较高有关。慢性负荷与MetS的1.85高比值（95%置信区间：1.11，3.09）相关。睡眠特征与代谢综合征无关。没有证据表明睡眠介导了慢性负荷-MetS关系。慢性压力负担可能是睡眠不良和代谢综合征的一个新的危险因素。
Chronic exposure to stress is associated with metabolic syndrome (MetS), but the mechanism is unclear. We investigated associations between chronic burden, sleep and MetS in the CARDIA Study. Chronic burden was self-reported (2000-2001) according to experiences with stressors for longer than 6 months. Wrist actigraphy-measured sleep duration and sleep efficiency were collected for 6-days; sleep duration, sleep quality and daytime sleepiness were self-reported (2003-2004). MetS was measured during the clinic visit, 2005-2006. Multivariable logistic and Cox proportional hazard models were fit to determine the associations of interest. Mediation by sleep was assessed using the product of coefficients approach. Among participants (N=606), the average age was 40 years (standard deviation=3.6), 58% were female, and 43% were Black. The prevalence of chronic burden, short sleep (≤6 hours), and MetS was 35%, 43% and 20.5%, respectively. High vs. low chronic burden was associated with shorter self-reported sleep duration and higher daytime sleepiness. Chronic burden was associated with 1.85 higher odds (95% confidence interval:1.11, 3.09) of MetS. Sleep characteristics were not associated with MetS. There was no evidence that sleep mediated the chronic burden-MetS relation. Burden of chronic stress may be an emerging novel risk factor for both poor sleep and MetS.