Ionic conduction, rectification, and selectivity in single conical nanopores
Ionic conduction, rectification, and selectivity in single conical nanopores
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DOI：
10.1063/1.2179797
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发表时间：
2006-03-14
影响因子：
4.4
通讯作者：
Ramírez, P
中科院分区：
文献类型：
--
作者：
Cervera, J;Schiedt, B;Ramírez, P
现代的径迹刻蚀方法可以制备含有单一带电圆锥形纳米孔的膜，由于表面孔道电荷与水溶液中可移动离子的电相互作用，该纳米孔显示出高的离子渗透选择性。该纳米孔在生物分子的电助单粒子检测、分析和分离方面具有潜在的应用前景。我们详细地从理论和实验上解释了孔半径和电解液浓度对电流-电压和电流-浓度曲线的影响。所使用的物理模型基于Nernst-Planck和Poisson方程。由于描述不同电压和浓度下离子输运的连续介质模型的有效性被认为是未来应用建模的主要问题之一，因此特别关注对纳米孔固定电荷和受限于内溶液的缩小体积中的可移动电荷之间的电学相互作用的基本理解。
Modern track-etching methods allow the preparation of membranes containing a single charged conical nanopore that shows high ionic permselectivity due to the electrical interactions of the surface pore charges with the mobile ions in the aqueous solution. The nanopore has potential applications in electrically assisted single-particle detection, analysis, and separation of biomolecules. We present a detailed theoretical and experimental account of the effects of pore radii and electrolyte concentration on the current-voltage and current- concentration curves. The physical model used is based on the Nernst-Planck and Poisson equations. Since the validity of continuum models for the description of ion transport under different voltages and concentrations is recognized as one of the main issues in the modeling of future applications, special attention is paid to the fundamental understanding of the electrical interactions between the nanopore fixed charges and the mobile charges confined in the reduced volume of the inside solution.