Persistent spatial working memory deficits in rats with bilateral cortical microgyria
Persistent spatial working memory deficits in rats with bilateral cortical microgyria
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DOI：
10.1186/1744-9081-4-45
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发表时间：
2008-10-01
影响因子：
5.1
通讯作者：
Chrobak, James J.
中科院分区：
文献类型：
--
作者：
Fitch, R. Holly;Breslawski, Heather;Chrobak, James J.
背景：皮质神经元迁移的异常（例如。例如，在一个实施例中，小脑回（MG）和/或异位与人类群体中的多种语言和认知缺陷相关。在啮齿类动物中，出生后局灶性冷冻损伤导致形成类似于人类睡眠障碍大脑中所见的皮质小脑回，并导致随后的快速听觉处理缺陷，类似于人类语言障碍人群中报告的缺陷。因此，收敛的研究结果支持正在进行的研究，在大鼠神经元迁移的中断作为一个假定的模型，以提供对人类语言障碍的见解。由于使用语言和非语言任务的工作记忆缺陷也是睡眠障碍人群的特征，本研究探讨了脑内诱导的双侧皮质小回（MG）对成年雄性大鼠工作记忆的影响。一个延迟匹配到样本的径向水迷宫任务，其中目标臂每天在八个位置之间变化，用于评估MG（n = 8）和假手术（n = 10）同窝仔的工作记忆表现。在60次测试中，（每个阶段包括一次延迟前样本试验和一次延迟后测试试验），所有的大鼠都表现出学习能力，这通过总体测试错误的显著减少来证明。然而，在最初的测试中，MG大鼠犯的错误比假的要多得多，并且这种记忆缺陷在60天（12周）的测试后仍然很明显。对日常错误模式进行的分析表明，在测试过程中，MG大鼠利用了一种策略类似于shams（但有效性较低，如更多的错误所示）。结论：这些结果表明，在大鼠的空间工作记忆系统的持续异常与诱导中断的新皮层神经元迁移。
Background: Anomalies of cortical neuronal migration (e. g., microgyria (MG) and/or ectopias) are associated with a variety of language and cognitive deficits in human populations. In rodents, postnatal focal freezing lesions lead to the formation of cortical microgyria similar to those seen in human dyslexic brains, and also cause subsequent deficits in rapid auditory processing similar to those reported in human language impaired populations. Thus convergent findings support the ongoing study of disruptions in neuronal migration in rats as a putative model to provide insight on human language disability. Since deficits in working memory using both verbal and non-verbal tasks also characterize dyslexic populations, the present study examined the effects of neonatally induced bilateral cortical microgyria (MG) on working memory in adult male rats.Methods: A delayed match-to-sample radial water maze task, in which the goal arm was altered among eight locations on a daily basis, was used to assess working memory performance in MG ( n = 8) and sham (n = 10) littermates.Results: Over a period of 60 sessions of testing (each session comprising one pre-delay sample trial, and one post-delay test trial), all rats showed learning as evidenced by a significant decrease in overall test errors. However, MG rats made significantly more errors than shams during initial testing, and this memory deficit was still evident after 60 days (12 weeks) of testing. Analyses performed on daily error patterns showed that over the course of testing, MG rats utilized a strategy similar to shams (but with less effectiveness, as indicated by more errors).Conclusion: These results indicate persistent abnormalities in the spatial working memory system in rats with induced disruptions of neocortical neuronal migration.