Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells.
Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells.
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激活的 PPARgamma 靶向抑制肺癌细胞增殖的表面和细胞内信号。
DOI：
10.1155/2008/254108
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发表时间：
2008
期刊：
影响因子：
2.9
通讯作者：
Roman,Jesse
中科院分区：
文献类型：
--
作者：
Han,ShouWei;Roman,Jesse
过氧化物酶体增殖物激活受体（PPARs）是属于核激素受体超家族的配体激活的转录因子。 他们在20世纪90年代的发现提供了对参与能量稳态控制，细胞分化，增殖和凋亡调节以及与炎症和癌症生物学相关的重要生物学和病理学过程的调节等细胞机制的见解。 从那时起，PPARs已成为针对包括癌症在内的许多疾病的治疗方法开发的令人兴奋的靶标。 PPARs在包括肺癌在内的许多肿瘤中表达，其功能与癌发生过程有关。 因此，人们正在该领域进行深入研究，希望发现治疗肺癌的新的PPAR相关治疗靶点。 本文综述了这一领域的研究进展，并重点介绍了该家族成员（PPARγ）影响肺肿瘤细胞生物学的机制。
Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis, the regulation of cell differentiation, proliferation, and apoptosis, and the modulation of important biological and pathological processes related to inflammation and cancer biology, among others. Since then, PPARs have become an exciting target for the development of therapies directed at many disorders including cancer. PPARs are expressed in many tumors including lung cancer, and their function has been linked to the process of carcinogenesis. Consequently, intense research is being conducted in this area with the hope of discovering new PPAR‐related therapeutic targets for the treatment of lung cancer. This review summarizes the research being conducted in this area, and focuses on the mechanisms by which a member of this family (PPARγ) is believed to affect lung tumor cell biology.