Dynamic combinatorial libraries: new opportunities in systems chemistry
Dynamic combinatorial libraries: new opportunities in systems chemistry
复制标题
DOI：
10.1039/c0cc03759a
复制
发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Otto, Sijbren
中科院分区：
文献类型：
--
作者：
Hunt, Rosemary A. R.;Otto, Sijbren
组合化学是选择具有特殊性质的分子的工具。动态组合化学一开始的目标就是这样。然而，与普通的组合化学不同，动态库的互连性给了它们一个额外的维度。在系统水平上理解这些分子网络对于它们作为选择工具的使用是必不可少的，并在系统化学中创造了令人兴奋的新机会。在这篇专题文章中，我们讨论了与动态组合库的高级开发相关的选定示例和考虑因素，以实现其最初设想的识别强结合相互作用的目的。还审查的例子说明了网络行为和可逆化学方面的复杂性日益增加的趋势。最后讨论了动态组合化学在自组装、输运和自复制等方面的新应用。
Combinatorial chemistry is a tool for selecting molecules with special properties. Dynamic combinatorial chemistry started off aiming to be just that. However, unlike ordinary combinatorial chemistry, the interconnectedness of dynamic libraries gives them an extra dimension. An understanding of these molecular networks at systems level is essential for their use as a selection tool and creates exciting new opportunities in systems chemistry. In this feature article we discuss selected examples and considerations related to the advanced exploitation of dynamic combinatorial libraries for their originally conceived purpose of identifying strong binding interactions. Also reviewed are examples illustrating a trend towards increasing complexity in terms of network behaviour and reversible chemistry. Finally, new applications of dynamic combinatorial chemistry in self-assembly, transport and self-replication are discussed.