Hemodynamic assessment of amrinone. A new inotropic agent.
Hemodynamic assessment of amrinone. A new inotropic agent.
复制标题
氨力农的血流动力学评估。
DOI：
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发表时间：
1978
影响因子：
158.5
通讯作者：
A. Alousi
中科院分区：
文献类型：
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作者：
J. Benotti;W. Grossman;E. Braunwald;D. Davolos;A. Alousi
氨力农是一种新的联吡啶衍生物，在实验制剂中具有正性肌力作用，狗口服有效。为了评估其对人体的直接影响，我们通过心导管术研究了8例充血性心力衰竭患者对氨力农（静脉注射1.85至3.5 mg/kg）的血流动力学反应，这些患者已经接受了全剂量的洋地黄。注意到以下统计学显著（P小于0.01）效应：心脏指数从平均+/-1S.D.每分钟每平方米1.8 +/- 0.3至2.6 +/- 0.3升;左心室压力上升峰值从每秒849 +/- 233上升至1206 +/- 456毫米汞柱;左心室舒张末期压从25 +/- 9下降至14 +/- 7毫米汞柱;肺毛细血管压从28 +/- 8降至15 +/- 4 mm Hg;右心房压从12 +/- 6降至7 +/- 5 mm Hg。平均心率不变，主动脉平均压略有下降（86 +/- 10至80 +/- 7 mm Hg，P <0.025）。未观察到毒性。氨力农的作用机制尚未明确，作为心力衰竭的可能治疗方法值得进一步研究。
Amrinone, a new bipyridine derivative, exerts a positive inotropic action in experimental preparations and is effective when administered orally to dogs. To assess its immediate effects in man, we studied by cardiac catheterization the hemodynamic responses to amrinone (1.85 to 3.5 mg per kilogram given intravenously) in eight patients with congestive heart failure already receiving full doses of digitalis. the following statistically significant (P less than 0.01) effects were noted: cardiac index increased from a mean +/- 1 S.D. of 1.8 +/- 0.3 to 2.6 +/- 0.3 liters per minute per square meter; peak rate of left ventricular pressure rise rose from 849 +/- 233 to 1206 +/- 456 mm Hg per second; left ventricular end-diastolic pressure fell from 25 +/- 9 to 14 +/- 7 mm Hg; pulmonary-capillary pressure fell from 28 +/- 8 to 15 +/- 4 mm Hg; and right atrial pressure fell from 12 +/- 6 to 7 +/- 5 mm Hg. Mean heart rate was unchanged, and aortic mean pressure declined slightly (86 +/- 10 to 80 +/- 7 mm Hg, P less than 0.025). No toxicity was observed. Amrinone, whose mechanism of action has not yet ben defined, warrants further study as a possible treatment for heart failure.