Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia.
Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia.
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DOI：
10.1038/s41598-017-03542-x
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发表时间：
2017-06-13
影响因子：
4.6
通讯作者：
Takano T
中科院分区：
文献类型：
--
作者：
Fujita T;Feng C;Takano T
针灸是治疗广谱慢性疼痛的一种替代疗法。然而，由于各种临床研究中评估的疗效存在争议，其有效性仍存在争议。此外，个体之间的差异性使结果的可预测性变得复杂，这阻碍了针灸融入主流疼痛管理计划。鉴于我们以前的研究发现，针灸的镇痛作用是由腺苷A1受体激活在穴位介导的，我们在这里报告，在急性和慢性动物疼痛模型，口服咖啡因，一种有效的腺苷受体拮抗剂，干扰针灸镇痛，即使在低剂量。在穴位局部给予咖啡因足以消除镇痛作用，消除咖啡因的全身作用。这种干扰是可逆的，因为咖啡因戒断在第二天完全恢复了针灸的疗效，长期暴露于咖啡因并没有改变穴位A1受体的表达。结合起来，这些数据表明，微量的咖啡因可以可逆地阻断针灸的镇痛作用，在针灸过程中控制咖啡因的摄入可能会改善疼痛管理的结果。
Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of acupuncture into mainstream pain management programs. In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose. Local administration of caffeine at the acupuncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caffeine. Such interference was reversible, as caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point. Combined, these data indicate that a trace amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffeine consumption during acupuncture may improve pain management outcomes.