The binding of steroid hormones to degranulated microsomes from rat-liver endoplasmic reticulum.
The binding of steroid hormones to degranulated microsomes from rat-liver endoplasmic reticulum.
复制标题
类固醇激素与大鼠肝内质网脱粒微粒体的结合。
DOI：
--
复制
发表时间：
1972
期刊：
影响因子：
--
通讯作者：
B. Rabin
中科院分区：
文献类型：
--
作者：
C. A. Blyth;M. Cooper;A. Roobol;B. Rabin
1
雄性大鼠肝脏光滑的网状膜含有雌二醇的高亲和力结合部位。来自女性的类似的膜含有类似的睾丸激素部位。
2.
用EDTA(脱颗粒膜)去除多聚体的粗糙膜，不包含对这两种激素的高亲和力结合部位。
3.
脱颗粒膜的乙酸乙酯萃取物含有能封闭同性光滑膜上高亲和力结合部位的物质，但不能阻断异性光滑膜上的高亲和力结合部位。
4.
这些提取物促进核糖体附着在同性光滑的膜上，但不促进异性。
5.
从雄性和雌性脱粒膜中提取的乙酸乙酯分别含有雌二醇和睾酮的物质。
1
Smooth reticular membranes from male rat liver contain high affinity binding sites for oestradiol. Similar membranes from females contain analogous sites for testosterone.
2
Rough membranes from which polysomes have been removed by EDTA (degranulated membranes), contain no high affinity binding sites for either hormone.
3
Ethyl acetate extracts of degranulated membranes contain materials which block the high affinity binding sites on smooth membranes of the same but not the opposite sex.
4
These extracts promote the attachment of ribosomes to smooth membranes of the same but not the opposite sex.
5
The ethyl acetate extracts from male and female degranulated membranes contain substances which behave like oestradiol and testosterone, respectively.