Management of erythropoiesis: cross-sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people
Management of erythropoiesis: cross-sectional study of the relationships between erythropoiesis and nutrition, physical features, and adiponectin in 3519 Japanese people
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DOI：
10.1111/ejh.12250
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发表时间：
2014-04-01
影响因子：
3.1
通讯作者：
Kato, Takeo
中科院分区：
文献类型：
--
作者：
Kohno, Kei;Narimatsu, Hiroto;Kato, Takeo
尽管红细胞异常（贫血和红细胞增多症）是常见的病理状况，但关于边界异常的信息并不多。在这项研究中，对中老年男性和女性进行了一项横断面研究，分析红细胞生成与营养、身体特征和实验室检查结果之间的关系。该研究包括 3519 名日本人（1579 名男性和 1940 名女性），年龄在 40 岁及以上。方差分析显示，有贫血倾向的人群年龄较大，体重指数和舒张压较低，血清脂联素和肌酐较高。多元回归分析显示，脂联素、甘油三酯和总蛋白是影响男性和女性红细胞生成的常见因素。肝、肾和心脏功能也是男性和绝经后女性红细胞生成的相关因素。此外，酒精、维生素和碳水化合物等营养因素也显着参与男性红细胞生成，但无论是绝经前还是绝经后女性，都没有显着参与红细胞生成的营养因素。这项研究表明，影响红细胞生成的因素在男性、绝经前女性和绝经后女性之间存在差异，这表明针对每组人群适当调整红细胞生成管理至关重要。
Although erythroid abnormalities (anemia and polycythemia) are commonly observed pathological conditions, not much information about borderline abnormalities is available. In this study, a cross-sectional study to analyze the relationships between erythropoiesis and nutrition, physical features, and laboratory test findings was conducted in middle-aged and older men and women. The study included 3519 Japanese people (1579 men and 1940 women), age 40years and over. Analysis of variance showed that the group with a tendency to anemia was older, had a lower body mass index and diastolic blood pressure, and had higher serum adiponectin and creatinine. Multiple regression analysis showed that adiponectin, triglycerides, and total protein were common factors that affected erythropoiesis in both men and women. Hepatic, renal, and cardiac functions were also factors involved in erythropoiesis in men and in postmenopausal women. In addition, nutrient factors such as alcohol, vitamins, and carbohydrates were also significantly involved in erythropoiesis in men, but there were no significant nutrient factors involved in erythropoiesis in either premenopausal or postmenopausal women. This study showed that factors that influence erythropoiesis differ between men, premenopausal women, and postmenopausal women, and it suggested that appropriately modifying erythropoiesis management for each group of people is essential.