Diagnosis and spectrum of melamine-related renal disease: Plausible mechanism of stone formation in humans
Diagnosis and spectrum of melamine-related renal disease: Plausible mechanism of stone formation in humans
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DOI：
10.1016/j.cca.2008.12.035
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发表时间：
2009-04-01
影响因子：
5
通讯作者：
Tam, Paul Kwong-Hang
中科院分区：
文献类型：
--
作者：
Lam, Ching-Wan;Lan, Lawrence;Tam, Paul Kwong-Hang
背景：食用三聚氰胺污染的牛奶后影响儿童尿路结石的流行正在展开。我们定义了该疾病的临床病理特征，用于诊断、监测和治疗这组患者。方法：对有尿石症超声表现的暴露儿童进行临床病理研究。尿液中的三聚氰胺和三聚氰尿酸水平用质谱法测定。结果：疾病严重程度不同，从急性肾功能衰竭伴肾积水到有症状或无症状的结石伴或不伴异常尿分析。所有病例均为年龄≥50%的有尿石症易感尿代谢危险因素的病例。多数结石位于肾盂内，超声测量2.5 ~ 18mm。我们发现肾结石大小和尿中三聚氰胺浓度之间有很强的相关性。的石头
Background: An epidemic of urinary stones affecting children after consumption of melamine tainted milk is unfolding. We defined clinicopathological features of the disease for diagnosis, monitoring, and treatment of this group of patients.Methods: A clinicopathological study on exposed children with ultrasonographic evidence of urolithiasis was conducted. Melamine and cyanuric acid levels in the urine were determined by mass spectrometry.Results: Disease severity varied from acute renal failure with hydronephrosis to symptomatic or asymptomatic stones with or without abnormal urinalysis. All cases were aged 50% cases having predisposing urinary metabolic risk factors for urolithiasis. Most of the stones were located in the renal pelvis and measured 2.5-18 mm by ultrasonography. We found a strong correlation between renal stone size and urinary melamine concentration. For stones