Effects of attention and emotion on repetition priming and their modulation by cholinergic enhancement
Effects of attention and emotion on repetition priming and their modulation by cholinergic enhancement
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DOI：
10.1152/jn.00776.2002
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发表时间：
2003-08-01
影响因子：
2.5
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Bentley, P;Vuilleumier, P;Dolan, RJ
我们研究了重复面孔的行为和神经效应是否受到选择性注意、情绪和胆碱能增强等独立因素的调节。面孔重复发生在任务相关(空间注意)或任务无关(无人注意)刺激之间；面孔可能是恐惧的，也可能是中性的；受试者要么接受安慰剂，要么接受毒扁豆碱。在安慰剂组中，重复(即启动)的反应时间优势在注意力水平之间没有差异，但会因情绪而减弱。与中性面孔相比，颞枕下皮质对有注意和无注意面孔的重复次数减少，对情绪面孔的重复减少程度相同或更大。相比之下，在外侧眼眶前额叶皮质中，情绪面孔相对于中性面孔的重复次数减少是减弱的。这些结果区分了感觉皮层区域的自动重复效应和眼眶额叶皮质中情绪调节的重复效应，后者与行为效应平行。在毒扁豆碱作用下，与安慰剂不同，行为重复效应只对被关注的面孔有选择性地被看到，而情绪面孔不再损害启动。毒扁豆碱增强了被关注面孔枕下皮层的重复次数，并逆转了与眼眶额叶外侧皮质的重复次数。因此，我们表明胆碱能增强既增强了启动的神经特征，又调节了注意力和情绪对重复的行为和神经后果的影响。
We examined whether behavioral and neural effects of repeating faces are modulated by independent factors of selective attention, emotion, and cholinergic enhancement, during functional MRI. Face repetition occurred either between task-relevant ( spatially attended) or task-irrelevant ( unattended) stimuli; faces could be fearful or neutral; subjects received either placebo or physostigmine. Under placebo, a reaction time advantage occurred with repetition (i.e., priming) that did not differ between levels of attention, but was attenuated with emotion. Inferior temporo-occipital cortex demonstrated repetition decreases to both attended and unattended faces, and showed either equivalent or greater repetition decreases with emotional compared with neutral faces. By contrast, repetition decreases were attenuated for emotional relative to neutral faces in lateral orbitofrontal cortex. These results distinguish automatic repetition effects in sensory cortical regions from repetition effects modulated by emotion in orbitofrontal cortex, which parallel behavioral effects. Under physostigmine, unlike placebo, behavioral repetition effects were seen selectively for attended faces only, whereas emotional faces no longer impaired priming. Physostigmine enhanced repetition decreases in inferior occipital cortex selectively for attended faces, and reversed the emotional interaction with repetition in lateral orbitofrontal cortex. Thus we show that cholinergic enhancement both augments a neural signature of priming and modulates the effects of attention and emotion on behavioral and neural consequences of repetition.