Immune status of children one to four years of age as determined by history and antibody measurement.
Immune status of children one to four years of age as determined by history and antibody measurement.
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通过病史和抗体测量确定一岁至四岁儿童的免疫状态。
DOI：
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发表时间：
1973
影响因子：
158.5
通讯作者：
P. Parkman
中科院分区：
文献类型：
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作者：
E. Gold;A. Février;M. Hatch;K. Herrmann;W. L. Jones;R. Krugman;P. Parkman
对居住在三个城市和一个郊区人口普查区的1至4岁儿童的血清抗体水平进行了测量，结果表明，总研究人口的63%易感染风疹，约33%的人麻疹抗体滴度不足。在整个研究组中，白喉和破伤风的抗毒素水平分别为24%和7%。这些儿童中有很大一部分（57%）对一种或多种脊髓灰质炎病毒的血清抗体水平低于10。许多人在建议的免疫接种次数后抗体水平很低;其他人没有接种足够的小儿麻痹症疫苗。虽然那些水平低的人可能不会感染麻痹性疾病，但如果再次感染野生脊髓灰质炎病毒，他们可能会将传染因子传播给环境中的易感人群。应加大力度为所有学龄前儿童接种疫苗。咨询委员会应考虑定期再免疫的必要性。（《新英格兰医学杂志》289：231-235，1973）
Abstract Measurement of serum antibody levels in children one to four years old, living in three city and one suburban census tract, revealed that 63 per cent of the total study population were susceptible to rubella and approximately 33 per cent had inadequate titers of measles antibody. Antitoxin levels to diphtheria and tetanus were low in 24 and 7 per cent respectively of the entire study group. A large proportion (57 per cent) of these children had serum antibody levels of less than 10 to one or more types of poliovirus. Many had low antibody levels after the recommended number of immunizations; others had not received adequate poliomyelitis vaccine. Although those with low levels may not contract paralytic disease, if reinfected with wild poliovirus, they may spread the infectious agent to susceptible persons in the environment. Increased effort should be made to immunize all preschool children. Advisory committees should consider the need for periodic reimmunization. (N Engl J Med 289:231–235, 1973)