Functional organization of color domains in V1 and V2 of macaque monkey revealed by optical imaging
Functional organization of color domains in V1 and V2 of macaque monkey revealed by optical imaging
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DOI：
10.1093/cercor/bhm081
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发表时间：
2008-03-01
期刊：
影响因子：
3.7
通讯作者：
Roe, Anna W.
中科院分区：
文献类型：
--
作者：
Lu, Haidong D.;Roe, Anna W.
猕猴视觉皮层V1和V2区具有独特的细胞色素氧化酶（cytochrome-oxidase， CO）染色模式。最初的电生理学研究将V1中的CO斑点与表面特性（如颜色和亮度）的处理联系起来，将CO斑点与轮廓信息处理联系起来。然而，许多后续研究显示了有争议的结果，一些支持这一建议，而另一些则未能发现blobs和interblobs之间的显着功能差异。在这项研究中，我们使用光学成像来绘制V1和V2的颜色选择反应。在V1中，我们发现了引人注目的“斑点状”颜色反应模式。光学图谱和CO染色组织的精细比对显示V1的颜色域与CO斑点密切相关。我们还发现V1的色域沿眼优势柱中心排列。此外，V1中的色团具有较低的取向选择性，并且不与取向域中心重叠。在V2中，色域与细条纹重合；方向选择区域与粗条纹和浅条纹相吻合。我们得出结论，颜色和取向选择反应优先位于V1和V2中不同的CO室。我们建议术语“blob”包含V1中的“CO blob”和“color domain”的概念。
Areas V1 and V2 of Macaque monkey visual cortex are characterized by unique cytochrome-oxidase (CO)-staining patterns. Initial electrophysiological studies associated CO blobs in V1 with processing of surface properties such as color and brightness and the interblobs with contour information processing. However, many subsequent studies showed controversial results, some supporting this proposal and others failing to find significant functional differences between blobs and interblobs. In this study, we have used optical imaging to map color-selective responses in V1 and V2. In V1, we find striking "blob-like" patterns of color response. Fine alignment of optical maps and CO-stained tissue revealed that color domains in V1 strongly associate with CO blobs. We also find color domains in V1 align along centers of ocular dominance columns. Furthermore, color blobs in V1 have low orientation selectivity and do not overlap with centers of orientation domains. In V2, color domains coincide with thin stripes; orientation-selective domains coincide with thick and pale stripes. We conclude that color and orientation-selective responses are preferentially located in distinct CO compartments in V1 and V2. We propose that the term "blob" encompasses both the concept of "CO blob" and "color domain" in V1.