Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering
Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering
复制标题
DOI：
10.1161/01.cir.94.10.2369
复制
发表时间：
1996-11-15
期刊：
影响因子：
37.8
通讯作者：
Hodis, HN
中科院分区：
文献类型：
--
作者：
Azen, SP;Qian, DJ;Hodis, HN
研究背景：越来越多的实验、流行病学和临床证据表明，抗氧化维生素摄入与冠心病风险降低之间存在关联。使用数据的胆固醇降低动脉粥样硬化研究（CLAS），我们探讨了协会的自我选择的补充抗氧化剂维生素的摄入量对早期preinjury atherosclerosis.Methods和Results的进展速度是一个动脉成像试验中，不吸烟的40- 59岁的男性与以前的冠状动脉旁路移植手术被随机分配到考来替泊/烟酸加饮食或安慰剂加饮食。采用高分辨率B型超声定量测定146例受试者的颈总动脉远端壁内膜中层厚度（IMT），以确定早期侵入前动脉粥样硬化的进展率。根据营养补充剂数据库，22例受试者的试验期间平均补充维生素E摄入量大于或等于100 IU/天（高使用者），29例受试者的试验期间平均补充维生素C摄入量大于或等于250 mg/天（高使用者）。在安慰剂组中，与低维生素E使用者相比，高补充维生素E使用者的颈动脉IMT进展较少（0.008 vs 0.023 mm/y，P= 0.03）。维生素E的药物组内没有效果被发现。维生素C的药物或安慰剂组内没有效果被发现。结论补充维生素E的摄入似乎是有效的，在减少动脉粥样硬化的进展，在未接受降脂药物治疗的受试者，而该过程仍然局限于动脉壁（早期侵入性动脉粥样硬化）。
Background There is accumulating experimental, epidemiological, and clinical evidence of an association between antioxidant vitamin intake and reduced risk of coronary heart disease. Using data from the Cholesterol Lowering Atherosclerosis Study (CLAS), we explored the association of self-selected supplementary antioxidant vitamin intake on the rate of progression of early preintrusive atherosclerosis.Methods and Results CLAS was an arterial imaging trial in which nonsmoking 40- to 59-year-old men with previous coronary artery bypass graft surgery were randomized to colestipol/niacin plus diet or placebo plus diet. The rate of progression of early preintrusive atherosclerosis was determined in 146 subjects using high-resolution B-mode ultrasound quantification of the distal common carotid artery far wall intima-media thickness (IMT). From the nutritional supplement database, 22 subjects had an on-trial average supplementary vitamin E intake of greater than or equal to 100 IU per day (high users) and 29 subjects had an average on-trial supplementary vitamin C intake of greater than or equal to 250 mg per day (high users). Within the placebo group, less carotid IMT progression was found for high supplementary vitamin E users when compared with low vitamin E users (0.008 versus 0.023 mm/y, P=.03). No effect of vitamin E within the drug group was found. No effect of vitamin C within the drug or placebo group was found.Conclusions Supplementary vitamin E intake appears to be effective in reducing the progression of atherosclerosis in subjects not treated with lipid-lowering drugs while the process is still confined to the arterial wall (early preintrusive atherosclerosis).