Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-KB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats
Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-KB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats
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山奈酚通过抑制油酸诱导的 HepG2 细胞和高脂饮食诱导的大鼠中的 NF-KB 通路，防止单纯性脂肪变性发展为非酒精性脂肪性肝炎
DOI：
10.1016/j.jff.2021.104655
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发表时间：
2021-08-02
影响因子：
5.6
通讯作者：
Sun, Wenlong
中科院分区：
文献类型：
--
作者：
Liu, Panpan;Wu, Peixuan;Sun, Wenlong
目前，非酒精性脂肪性肝病(NAFLD)是世界范围内最常见的肝病，防治NAFLD需要更多的功能食品。山奈酚可从茶叶、西兰花、蜂胶、葡萄柚等绿色植物中提取。然而，关于山奈酚对NAFLD的预防作用缺乏较为系统的研究。在本研究中，我们利用网络药理学的方法，发现山奈酚可以通过多个靶点来预防NAFLD的发展，例如，山奈酚抑制炎症，改善胰岛素抵抗和减轻氧化应激。此外，我们还证实了山奈酚在体内外通过抑制核转录活性抑制炎症反应，从而阻止NAFLD的发展。我们的研究支持将山奈酚作为功能性食品或膳食补充剂用于NAFLD的预防和治疗。此外，本研究还有助于了解其他多种黄酮类化合物的抗非酒精性脂肪肝作用机制。
Currently, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and more functional foods are needed for NAFLD prevention and treatment. Kaempferol can be obtained from tea, broccoli, propolis, grapefruit and other green plants. However, relatively systematic studies concerning the preventative effects of kaempferol against NAFLD are lacking. In this study, using network pharmacological methods, we found that kaempferol could prevent the development of NAFLD by targeting multiple targets; for instance, kaempferol suppressed inflammation, improved insulin resistance and reduced oxidative stress. Furthermore, we confirmed that kaempferol could suppress inflammatory responses and prevent the development of NAFLD in vitro and in vivo by inhibiting the nuclear transcriptional activity of NF-KB. Our study supports the use of kaempferol as a functional food or dietary supplement for NAFLD prevention and treatment. In addition, this study could be beneficial for understanding the anti-NAFLD mechanism of many other flavonoids.