Controllable Molecule Transport and Release by a Restorable Surface-tethered DNA nanodevice.
Controllable Molecule Transport and Release by a Restorable Surface-tethered DNA nanodevice.
复制标题
可恢复表面束缚 DNA 纳米装置的可控分子传输和释放
DOI：
10.1038/srep28292
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发表时间：
2016-07-07
影响因子：
4.6
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Wang Z;Xu Y;Wang H;Liu F;Ren Z;Wang Z
在本文中，我们报道了一种新型的表面拴系DNA纳米器件，它可以呈现三种状态，并在pH的作用下发生构象变化。此外，电极表面的方便调节使这种DNA纳米器件的构造和操作具有可恢复性。为了充分利用这种DNA纳米器件，二茂铁(FC)被进一步用于制作分子器件。一方面，利用Fc获得的电化学信号可以方便、可靠地表征DNA纳米器件的状态开关。另一方面，FC可以引入β-环糊精-二茂铁(β-CD-FC)主客体体系，使该分子器件功能化。基于β-CD在不同状态下的不同电化学行为，该纳米器件可以实现β-CD在纳米尺度上的定向加载、传输和卸载。因此，这种DNA纳米器件在可控的分子传输和释放方面具有很好的应用前景，这对分子器件的设计具有重要的价值。
In this paper, we report a novel surface-tethered DNA nanodevice that may present three states and undergo conformational changes under the operation of pH. Besides, convenient regulation on the electrode surface renders the construction and operation of this DNA nanodevice restorable. To make full use of this DNA nanodevice, ferrocene (Fc) has been further employed for the fabrication of the molecular device. On one hand, the state switches of the DNA nanodevice can be characterized conveniently and reliably by the obtained electrochemical signals from Fc. On the other hand, β-cyclodextrin-ferrocene (β-CD-Fc) host-guest system can be introduced by Fc, which functionalizes this molecular device. Based on different electrochemical behaviors of β-CD under different states, this DNA nanodevice can actualize directional loading, transporting and unloading of β-CD in nanoscale. Therefore, this DNA nanodevice bares promising applications in controllable molecular transport and release, which are of great value to molecular device design.
影响因子：
10.8
作者：
Lee G;Hartung S;Hopfner KP;Ha T
通讯作者：
Ha T