STAT2: A shape-shifting anti-viral super STAT.
STAT2: A shape-shifting anti-viral super STAT.
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DOI：
10.4161/jkst.23633
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Farrar JD
中科院分区：
文献类型：
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作者：
Chowdhury FZ;Farrar JD
STAT2 在 STAT 转录因子家族中是独特的，因为它的激活主要由两类细胞表面受体驱动：I 型和 III 型干扰素受体。因此，STAT2 在宿主防御病毒感染方面发挥着关键作用。病毒已经进化到通过抑制 STAT2 表达、阻断其活性或靶向降解 STAT2 来靶向 STAT2。因此，这些病毒攻击导致了不同物种间 STAT2 基因的显着差异，而这在其他 STAT 家族成员中并未观察到。因此，STAT2的进化可能会保留其活性，并在面对不断变化的病毒群落时保护每个物种。
STAT2 is unique among the STAT family of transcription factors in that its activation is driven predominantly by only two classes of cell surface receptors: Type I and III interferon receptors. As such, STAT2 plays a critical role in host defenses against viral infections. Viruses have evolved to target STAT2 by either inhibiting its expression, blocking its activity, or by targeting it for degradation. Consequently, these viral onslaughts have driven remarkable divergence in the STAT2 gene across species that is not observed in other STAT family members. Thus, the evolution of STAT2 may preserve its activity and protect each species in the face of an ever-changing viral community.