Toll-like Receptors and Sepsis.
Toll-like Receptors and Sepsis.
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DOI：
10.1007/s11908-004-0034-1
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发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
Akira, Shizuo
中科院分区：
文献类型：
--
作者：
Ishii, Ken J;Akira, Shizuo
最近的证据表明，Toll样受体（TLR）在先天免疫中发挥重要作用，识别来自病原体的特定分子模式，包括脂质，蛋白质，DNA和RNA，并对抗病原体。每种TLR在表达模式、细胞内定位和信号传导途径上表现出差异，从而导致不同的免疫应答。由此产生的免疫激活增强了宿主对各种感染性生物的抵抗力。然而，在脓毒症的情况下，这种反应可能超过维持宿主体内平衡的阈值。TLR介导的先天免疫激活也诱导几种分子显示负调节TLR信号传导。因此，TLRs可能在脓毒症免疫应答的正性和负性调节中发挥重要作用。
Recent evidence suggests that Toll-like receptors (TLRs) play a major role in innate immunity to recognize specific molecular patterns derived from pathogens, including lipid, protein, DNA, and RNA, and to fight against pathogens. Each TLR displays a difference in the expression pattern, intracellular localization, and signaling pathway, resulting in the distinct immune responses. The resultant immune activation augments host resistance to a variety of infectious organisms. However, such responses may exceed the threshold to maintain host homeostasis in the case of sepsis. TLR-mediated innate immune activation also induces several molecules shown to negatively regulate TLR signaling. Thus, TLRs may play an important role in positive and negative regulation of immune responses during sepsis.