POLYMORPHISM OF ACTIN PARACRYSTALS INDUCED BY POLYLYSINE
POLYMORPHISM OF ACTIN PARACRYSTALS INDUCED BY POLYLYSINE
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DOI：
10.1083/jcb.93.2.452
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发表时间：
1982-01-01
影响因子：
7.8
通讯作者：
AEBI, U
中科院分区：
文献类型：
--
作者：
FOWLER, WE;AEBI, U
描述了一种诱导不同多态形式的[兔和鸡]肌动蛋白细丝准晶的方法。这种多态可能是由于单层准晶中相邻细丝的交错和/或极性的差异以及多层准晶中不同层的叠加所致。对于观察到的不同的多态形式和所使用的4种不同的肌动蛋白，定义细丝几何形状的螺旋参数是无法区分的。对这些准晶的分析应该提供一个参考结构，适用于从晶体数据获得的肌动蛋白单体的高分辨率模型的肌动蛋白细丝内的排列和取向。
A method for the induction of different polymorphic forms of [rabbit and chicken] actin filament paracrystals is described. This polymorphism was probably based on differences in the stagger and/or polarity of adjacent filaments in single-layered paracrystals and by superposition of different layers in multilayered paracrystals. The helical parameters defining the filament geometry were indistinguishable for the different polymorphic forms observed and for the 4 different actins used. Analysis of these paracrystals, some of which were ordered to better than 2.5 nm, should provide a reference structure suitable for alignment and orientation within the actin filament of high resolution models of the actin monomer obtained from crystal data.