Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift
Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift
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DOI：
10.1016/j.heares.2009.07.008
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发表时间：
2009-11-01
期刊：
影响因子：
2.8
通讯作者：
Guo, Yueliang Leon
中科院分区：
文献类型：
--
作者：
Lin, Cheng-Yu;Wu, Jiunn-Liang;Guo, Yueliang Leon
活性氧（ROS）的产生被认为是噪声性听力损失（NIHL）机制的一部分。谷氨酸是一种重要的细胞抗氧化剂，可限制ROS对细胞的损伤。本研究旨在探讨谷胱甘肽S-转移酶（GST）T1、GSTM 1和GST P1基因多态性对某钢铁厂58名男性噪声作业工人暂时性听阈偏移（TTS）的影响。在高频（HF，平均3、4和6 kHz）下的移位前听力损伤为30.7 dB HL（S.D.）。= 19.3）。每日噪声暴露量为83.0 dBA（S.D.）。= 5.0）。纯音测听（PTA）测得的高频时噪声诱发的TTS与每日噪声暴露量有关（p < 0.05）。通过组合分析发现，携带GSTT 1 null、GSTM 1 null和GSTP 1 Ile（105）/Ile（105）基因型的个体更易患NIHL。此外，GST基因多态性可能会改变噪声诱导TTS的易感性。(C)2009爱思唯尔有限公司版权所有。
The generation of reactive oxygen species (ROS) is thought to be part of the mechanism underlying noise-induced hearing loss (NIHL). Glutathione is an important cellular antioxidant that limits cell damage by ROS. We aimed to determine the effect of genetic polymorphisms of glutathione S-transferase (GST) T1, GSTM1, and GSTP1, on temporary threshold shift (TTS) in 58 noise-exposed male workers from a steel factory. The pre-shift hearing impairment at high frequency (HF, average of 3, 4, and 6 kHz) was 30.7 dB HL (S.D. = 19.3). The amount of daily noise exposure was 83.0 dBA (S.D. = 5.0). Noise-induced TTS at HF by pure-tone audiometry (PTA) was related to the daily noise exposure (p < 0.05). Based on combinatory analysis, we found that individuals carrying all genotypes with GSTT1 null, GSTM1 null, and GSTP1 Ile(105)/Ile(105) were more susceptible to NIHL These results suggest that pre-shift hearing impairment and daily noise exposure had impacts on TTS at HF by PTA. In addition, GST genetic polymorphisms may modify the susceptibility to noise-induced TTS. (C) 2009 Elsevier B.V. All rights reserved.