Genetic control of the immune response to myoglobin. VII. Antibody responses to myoglobin variants reveal that gene restriction of the antibody responses to myoglobin antigenic sites is dependent on the chemical properties of the sites.
Genetic control of the immune response to myoglobin. VII. Antibody responses to myoglobin variants reveal that gene restriction of the antibody responses to myoglobin antigenic sites is dependent on the chemical properties of the sites.
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对肌红蛋白免疫反应的遗传控制。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
Atassi Mz
中科院分区：
文献类型：
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作者：
C. Young;O'Connor Gp;Atassi Mz
先前的研究表明，抹香鲸肌红蛋白的免疫反应是受h -2相关的ir基因控制的。更重要的是，对合成抗原位点的反应都在不同的遗传控制下。在目前的研究中，我们研究了四种已知结构的不同肌红蛋白对抗体反应的遗传控制，以确定这种遗传控制是否受到位点性质变化的影响。结果表明，对蛋白质抗原上单个抗原位点反应的遗传控制不仅取决于宿主物种的遗传构成，还取决于单个位点的化学性质。研究表明，如果H-2亚区对特定抗原位点的反应进行适当改变，它们也可以识别以前在同源蛋白中无法识别的其他位点。
Previously it has been shown that the immune responses to sperm-whale myoglobin are under H-2-linked Ir-gene control. More importantly the responses to the synthetic antigenic sites are each under separate genetic control. In the present studies we investigated the genetic control of the antibody response to four different myoglobins of known structure, to determine whether this genetic control is influenced by changes in the properties of the sites. The results suggest that genetic control of the responses to individual antigenic sites on a protein antigen is not only determined by the genetic constitution of the host species but also by the chemical properties of the individual sites. It appears that the H-2 subregions mapping the responses to given antigenic sites can also recognize other sites, which were previously unrecognizable in a homologous protein, if their chemical properties are suitably altered.