Cipacinoids A-D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens
Cipacinoids A-D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens
复制标题
Cipacinoids A-D，来自 Cipadessa cinerascens 的四种具有螺环骨架的柠檬苦素类化合物
DOI：
10.1021/acs.orglett.5b03487
复制
发表时间：
2016-02-05
期刊：
影响因子：
5.2
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Yu, Jin-Hai;Liu, Qun-Fang;Yue, Jian-Min
从芫花中分离到4个具有螺旋环骨架的柠檬素，子叶酸A-D（1-4）。特别值得注意的是，化合物1 ~ 3在类柠檬素家族中首次具有17s构型。通过光谱数据、x射线晶体学和CD分析确定了它们具有绝对构型的结构。化合物1对蛋白酪氨酸磷酸酶1B （PTP1B）有中等抑制作用。
Four limonoids, cipacinoids A-D (1-4), with spirocyclic skeletons were isolated from Cipadessa cinerascens. It is particularly notable that compounds 1-3 had a 17S-configuration for the first time in the limonoid family. Their structures with absolute configurations were assigned by spectroscopic data, X-ray crystallography, and CD analysis. Compound 1 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibition.