Treatment of depression by drugs and psychotherapy.
Treatment of depression by drugs and psychotherapy.
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通过药物和心理治疗治疗抑郁症。
DOI：
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发表时间：
1974
影响因子：
17.7
通讯作者：
E. Paykel
中科院分区：
文献类型：
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作者：
G. Klerman;Albert DiMascio;Myrna M. Weissman;B. Prusoff;E. Paykel
预防抑郁症复发是一个紧迫的研究问题。作者测试了三环类抗抑郁药阿米替林和心理疗法单独和联合使用预防150例神经性抑郁症女性患者复发的效果。他们发现，接受阿米替林和很少心理治疗的患者复发率为12%，而接受更多心理治疗和不接受药物治疗的患者的复发率为16%。单纯药物治疗与药物联合心理治疗的疗效差异无统计学意义。但心理治疗对有社会适应和人际关系问题的患者是有益的。讨论了进一步研究的必要性和对治疗的影响。
Prevention of relapse following depression is a pressing research problem. The authors tested the efficacy of the tricyclic antidepressant amitriptyline and psychotherapy, alone and in combination, in preventing the relapse of 150 neurotic depressed female patients. They found that patients receiving amitriptyline and little psychotherapy had a 12-percent relapse rate, compared to a 16-percent rate for those receiving more psychotherapy and no medication. There was no significant difference between drug therapy alone or drug therapy in combination with psychotherapy. However, psychotherapy was beneficial to patients with problems of social adjustment and interpersonal relations. The need for further research and implications for treatment are discussed.