Ultrasound Imaging with Flexible Array Transducer for Pancreatic Cancer Radiation Therapy.
Ultrasound Imaging with Flexible Array Transducer for Pancreatic Cancer Radiation Therapy.
复制标题
超声成像具有用于胰腺癌辐射疗法的柔性阵列传感器。
DOI：
10.3390/cancers15133294
复制
发表时间：
2023-06-22
期刊：
影响因子：
5.2
通讯作者：
Ding, Kai
中科院分区：
文献类型：
--
作者：
Huang, Xinyue;Hooshangnejad, Hamed;China, Debarghya;Feng, Ziwei;Lee, Junghoon;Bell, Muyinatu A. Lediju;Ding, Kai
关键词：
超声（US）成像已被广泛用于图像引导放射治疗中的肿瘤跟踪。使用传统探头的US图像质量高度依赖于用户熟练程度和解剖结构变化，这严重阻碍了基于US的胰腺癌器官运动监测的使用。柔性阵列换能器是一种新颖的和有前途的解决方案，以解决传统的超声探头的局限性。同时，其强度和灵活的几何结构也使得图像重建和延迟求和（DAS）波束形成非常具有挑战性。延迟计算的不准确性导致散焦和失真的US图像。在这项研究中，我们提出了一种新的形状估计柔性阵列传感器，以加强腹部运动监测。胰腺癌是最致命的癌症类型之一，其3年生存率低于10%，并且大大受益于增强的放射治疗。器官运动监测有助于使正常组织免受高辐射，反过来，使剂量逐步增加到目标，这已被证明可以提高RT的有效性，使RT后生存率增加一倍和三倍。柔性阵列换能器是一种新颖的和有前途的解决方案，以解决传统的超声探头的局限性。我们提出了一种新的形状估计柔性阵列传感器使用两个顺序算法：（i）基于光学跟踪的系统，它使用在特定位置处附着到探头的光学标记坐标来实时估计阵列形状;（ii）全自动形状优化算法，它自动搜索最佳阵列形状，从而获得最高质量的重建图像。我们进行了体模和体内实验，以评估估计的阵列形状和重建的US图像的准确性。所提出的方法重建的US图像具有较低的半高宽（FWHM）的点散射，正确的纵横比的囊肿，和高匹配分数与地面真相。我们的研究结果表明，所提出的方法重建高质量的超声图像与显着更少的散焦和失真相比，没有任何校正。具体地说，自动优化方法将阵列形状估计误差减小到小于透射波的半波长，从而产生高质量的重建图像。
Ultrasound (US) imaging has been widely used for tumor tracking in image-guided radiotherapy. The quality of US images using conventional probes highly depends on user proficiency and anatomical changes, which has severely hindered the use of US-based organ motion monitoring for pancreatic cancer. The flexible array transducer is a novel and promising solution to address the limitation of conventional US probes. At the same time, its strength and flexible geometry also makes the image reconstruction and delay-and-sum (DAS) beamforming very challenging. Inaccuracy in delay calculation results in defocused and distorted US images. In this study, we proposed a novel shape estimation for flexible array transducer to enhance abdomen motion monitoring. Pancreatic cancer with less than 10% 3-year survival rate is one of deadliest cancer types and greatly benefits from enhanced radiotherapy. Organ motion monitoring helps spare the normal tissue from high radiation and, in turn, enables the dose escalation to the target that has been shown to improve the effectiveness of RT by doubling and tripling post-RT survival rate. The flexible array transducer is a novel and promising solution to address the limitation of conventional US probes. We proposed a novel shape estimation for flexible array transducer using two sequential algorithms: (i) an optical tracking-based system that uses the optical markers coordinates attached to the probe at specific positions to estimate the array shape in real-time and (ii) a fully automatic shape optimization algorithm that automatically searches for the optimal array shape that results in the highest quality reconstructed image. We conducted phantom and in vivo experiments to evaluate the estimated array shapes and the accuracy of reconstructed US images. The proposed method reconstructed US images with low full-width-at-half-maximum (FWHM) of the point scatters, correct aspect ratio of the cyst, and high-matching score with the ground truth. Our results demonstrated that the proposed methods reconstruct high-quality ultrasound images with significantly less defocusing and distortion compared with those without any correction. Specifically, the automatic optimization method reduced the array shape estimation error to less than half-wavelength of transmitted wave, resulting in a high-quality reconstructed image.
登录
查看更多内容
用于胰腺癌放射治疗的可生物降解水凝胶垫片保留十二指肠的剂量预测模型
DOI：
10.1016/j.ijrobp.2018.07.184
发表时间：
2018-11-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Feng Z;Rao AD;Cheng Z;Shin EJ;Moore J;Su L;Kim SH;Wong J;Narang A;Herman JM;McNutt T;Li D;Ding K
通讯作者：
Ding K
影响因子：
3.8
作者：
Hansen, Rune;Ravkilde, Thomas;Poulsen, Per Rugaard
通讯作者：
Poulsen, Per Rugaard
影响因子：
4.2
作者：
Chang, Junjie;Chen, Zhiheng;Lu, Chao
通讯作者：
Lu, Chao
影响因子：
3.8
作者：
Hooshangnejad, Hamed;Han-Oh, Sarah;Shin, Eun Ji;Narang, Amol;Rao, Avani Dholakia;Lee, Junghoon;McNutt, Todd;Hu, Chen;Wong, John;Ding, Kai
通讯作者：
Ding, Kai
影响因子：
4.7
作者：
Hooshangnejad H;Youssefian S;Narang A;Shin EJ;Rao AD;Han-Oh S;McNutt T;Lee J;Hu C;Wong J;Ding K
通讯作者：
Ding K