Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study
Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study
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DOI：
10.1016/j.ejrad.2014.01.024
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发表时间：
2014-05-01
影响因子：
3.3
通讯作者：
Yan, Fuhua
中科院分区：
文献类型：
--
作者：
Li, Qinghai;Li, Jinning;Yan, Fuhua
目的：目的：探讨弥散加权成像（DWI）在慢性肾脏病（CKD）肾脏病理诊断中的应用价值。根据肾脏病理的严重程度对CKD患者的肾活检标本进行评分，以确认病理类型。CKD患者根据病理评分分为三组：轻度、中度和重度。肾表观弥散系数（ADC）值和病理评分之间的关系进行了研究，采用皮尔逊相关和单因素方差分析。采用多元线性回归分析探讨肾脏ADC值与病理评分、肾小球滤过率、血清肌酐和年龄之间的关系。结果：肾ADC值与病理评分呈负相关（r=-0.633，P
Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD).Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal-Wallis H test was conducted to compare ADC values and pathology type.Results: Renal ADC values correlated negatively with pathology scores (r=-0.633, P