Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers
Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers
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DOI：
10.1136/gut.39.6.836
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发表时间：
1996-12-01
期刊：
影响因子：
24.5
通讯作者：
Sartor, RB
中科院分区：
文献类型：
--
作者：
Herfarth, HH;Mohanty, SP;Sartor, RB
背景与目的：白介素10(IL10)抑制单核/巨噬细胞和T淋巴细胞效应功能，本研究采用大鼠急、慢性肉芽肿性小肠结肠炎、肝炎和关节炎模型，观察IL10对大鼠急性和慢性肉芽肿性小肠结肠炎、肝炎和关节炎的影响。从注射PG-APS前12小时开始，每天皮下注射重组小鼠IL-10或赋形剂，连续治疗3天或17天。
Background and Aims-Interleukin 10 (IL10) inhibits monocyte/macrophage and T lymphocyte effector functions, This study examined the effect of systemically administered IL10 on acute and chronic granulomatous enterocolitis, hepatitis, and arthritis in a rat model.Methods-Lewis rats were injected intra-murally with streptococcal peptidoglycan-polysaccharide (PG-APS) polymers. Beginning 12 hours before PG-APS injection, rats were treated daily with subcutaneous murine recombinant IL10 or vehicle for three or 17 days.Results-IL10 attenuated acute enterocolitis in a dose dependent fashion (p