Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance data
Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance data
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DOI：
10.1016/s1473-3099(10)70225-5
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发表时间：
2011-01-01
影响因子：
56.3
通讯作者：
Fairley, Christopher K.
中科院分区：
文献类型：
--
作者：
Donovan, Basil;Franklin, Neil;Fairley, Christopher K.
背景四价人乳头瘤病毒(HPV)疫苗在临床试验中具有很高的疗效，但尚未有报道描述其在人群水平上的效果。从2007年7月起，澳大利亚成为第一个资助为所有12-26岁妇女提供疫苗接种方案的国家。我们在澳大利亚建立了一个全国监测网络，旨在确定2004-2009年生殖器疣的诊断趋势。方法我们获得了2004年1月至2009年12月期间在澳大利亚8个性健康服务机构就诊的新患者的人口因素、生殖器疣频率、HPV疫苗接种状况和性行为的标准化数据。我们使用X(2)分析来确定在接种疫苗开始之前和之后，被诊断为尖锐湿疣的患者比例的显著趋势。我们的主要兴趣群体是有资格获得免费疫苗接种的澳大利亚女性居民，尽管对没有资格获得免费疫苗接种的患者的数据进行了评估，包括26岁以上的女性、非居民女性和男性。在112083例性健康服务的新患者中，我们发现了9867例(9%)生殖器疣病例。在疫苗计划开始之前，女性或异性恋男性被诊断为生殖器疣的比例没有变化。接种疫苗后，年轻女性居民的生殖器疣诊断率下降(59%，p(趋势))
Background Quadrivalent human papillomavirus (HPV) vaccine has high efficacy in clinical trials but no reports describe its effects at a population level. From July, 2007, Australia was the first country to fund a vaccination programme for all women aged 12-26 years. We established a national surveillance network in Australia and aimed to identify trends in diagnoses of genital warts in 2004-09.Methods We obtained standardised data for demographic factors, frequency of genital warts, HPV vaccination status, and sexual behaviour for new patients attending eight sexual health services in Australia between January, 2004, and December, 2009. We used chi(2) analysis to identify significant trends in proportions of patients diagnosed with warts in periods before and after vaccination began. Our primary group of interest was female Australian residents who were eligible for free vaccination, although data were assessed for patients ineligible for free vaccination, including women older than 26 years of age, non-resident women, and men.Findings Among 112083 new patients attending sexual health services, we identified 9867 (9%) cases of genital warts. Before the vaccine programme started, there was no change in proportion of women or heterosexual men diagnosed with genital warts. After vaccination began, a decline in number of diagnoses of genital warts was noted for young female residents (59%, p(trend)