The role of adaptive T cell immunity in atherosclerosis
The role of adaptive T cell immunity in atherosclerosis
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DOI：
10.1194/jlr.r800092-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Tedgui, Alain
中科院分区：
文献类型：
--
作者：
Mallat, Ziad;Taleb, Soraya;Tedgui, Alain
现在有确凿的证据表明T细胞适应性免疫参与动脉粥样硬化形成。虽然最初的研究集中在免疫反应的致病性方面，但最近的研究清楚地表明，调节性T细胞的几个亚群在保护免受病变发展方面发挥着重要作用。在这里，我们回顾了目前有关致病性和调节性适应性T细胞免疫在动脉粥样硬化中的作用的知识，这些知识主要来自对该疾病小鼠模型的研究。Mallat，Z.，S. Taleb，H. Ait-Oufella和A.泰吉适应性T细胞免疫在动脉粥样硬化中的作用。J. Lipid Res. 2009. S364-S369。
There is now solid evidence that T cell adaptive immunity is involved in atherogenesis. While initial studies have focused on the pathogenic arm of the immune response, more recent work clearly suggests an important role for several subsets of regulatory T cells in the protection against lesion development. Here, we review the current knowledge on the role of both pathogenic and regulatory adaptive T cell immunity in atherosclerosis, generated mainly from the study of mouse models of the disease.-Mallat, Z., S. Taleb, H. Ait-Oufella, and A. Tedgui. The role of adaptive T cell immunity in atherosclerosis. J. Lipid Res. 2009. S364-S369.