Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in tubular and villous large-bowel adenomas with different grades of dysplasia.
Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in tubular and villous large-bowel adenomas with different grades of dysplasia.
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不同级别不典型增生的管状和绒毛状大肠腺瘤中癌胚抗原、分泌成分和上皮 IgA 的免疫组织化学评估。
DOI：
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发表时间：
1982
影响因子：
1.9
通讯作者：
P. Brandtzaeg
中科院分区：
文献类型：
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作者：
T. Rognum;O. Fausa;P. Brandtzaeg
在连续收集的513例大肠息肉中，选择管状腺瘤和绒毛状腺瘤，并与上皮异型增生的组织学分级相对应。对52例癌前病变和27例后癌上皮标记物进行免疫组织化学染色，检测癌胚抗原(CEA)、分泌成分(SC)和IgA。在两种类型的肿瘤之间，没有发现总体染色性质的一致差异。在这两种类型中，SC和上皮性IgA的染色强度随着异型增生程度的增加而降低，尤其是IgA。这一观察结果表明，癌变损害了柱状上皮产生SC的能力，并将其表达为介导二聚体IgA摄取的功能性受体。因此，大肠腺瘤中上皮性IgA的缺失可能是异型增生分级的有用的辅助指标。相反，CEA的存在似乎与上皮细胞的异常发育改变无关。
In a material of 513 consecutively collected large-bowel polyps, tubular and villous adenomas with corresponding histologic grades of epithelial dysplasia were selected. Fifty-two samples of the former and 27 of the latter category were evaluated semiquantitatively for immunohistochemical staining of the epithelial marker proteins carcinoembryonic antigen (CEA), secretory component (SC), and IgA. No consistent differences in the overall staining properties were found between the two types of tumours. In both categories the staining intensity for SC and epithelial IgA decreased with increasing degree of dysplasia, most strikingly so for IgA. This observation shows that the malignant alterations impair the capacity of the columnar epithelium to produce SC and to express it as a functional receptor mediating uptake of dimeric IgA. Thus, the absence of epithelial IgA in large-bowel adenomas may be a useful adjunct in grading of dysplasia. Conversely, the presence of CEA did not seem to be related to dysplastic alterations in the epithelium.