From HIV infection to AIDS: a dynamically induced percolation transition?
From HIV infection to AIDS: a dynamically induced percolation transition?
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DOI：
10.1098/rspb.2002.2095
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发表时间：
2002-10-07
影响因子：
4.7
通讯作者：
Bornholdt, S
中科院分区：
文献类型：
--
作者：
Kamp, C;Bornholdt, S
艾滋病发病过程中潜伏期分布异常的原因在很大程度上尚未解决。要了解观察到的潜伏期分布，以及根本没有发展成艾滋病的感染者的情况，一个关键因素是艾滋病毒与免疫系统之间长期斗争的动态。通过计算机模拟，我们研究了病毒基因组在变异和免疫系统的选择压力下的多样性。在非艾滋病毒感染中，病毒基因组在基因组空间中的大规模传播通常不会发生。在HIV感染的情况下，这可能会发生，因为病毒通过耗尽CD4(+)细胞而连续削弱免疫系统。在序列空间框架中，这导致了动态诱导的渗流转变，对应于艾滋病的发病。结果，我们得到了潜伏期分布的延长形状，以及有限部分没有发展为艾滋病的非进展者，与最近临床研究的结果进行了很好的比较。
The origin of the unusual incubation period distribution in the development of AIDS is largely unresolved. A key factor in understanding the observed distribution of latency periods, as well as the occurrence of infected individuals not developing AIDS at all, is the dynamics of the long-lasting struggle between HIV and the immune system. Using a computer simulation, we study the diversification of viral genomes under mutation and the selective pressure of the immune system. In non-HIV infections, vast spreading of viral genomes in genome space usually does not take place. In the case of an HIV infection, this may occur, as the virus successively weakens the immune system by the depletion of CD4(+) cells. In a sequence space framework, this leads to a dynamically induced percolation transition, corresponding to the onset of AIDS. As a result, we obtain a prolonged shape of the incubation period distribution, as well as a finite fraction of non-progressors that do not develop AIDS, comparing well with results from recent clinical research.