Sodium fluoride suppress proliferation and induce apoptosis through decreased insulin-like growth factor-I expression and oxidative stress in primary cultured mouse osteoblasts
Sodium fluoride suppress proliferation and induce apoptosis through decreased insulin-like growth factor-I expression and oxidative stress in primary cultured mouse osteoblasts
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氟化钠通过降低原代培养的小鼠成骨细胞中胰岛素样生长因子-I 的表达和氧化应激来抑制增殖并诱导细胞凋亡
DOI：
10.1007/s00204-011-0697-y
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发表时间：
2011-04
影响因子：
6.1
通讯作者：
Han, Bo
中科院分区：
文献类型：
--
作者：
Wang, Zhi;Yang, Xiaoyu;Yang, Shiyong;Ren, Gaixian;Ferreri, Miro;Su, Yong;Chen, Liben;Han, Bo
It has been reported that sodium fluoride suppressed proliferation and induced apoptosis in osteoblasts. However, the details about the mechanism at work in bone metabolism are limited. In this study, we further investigated the mechanisms of NaF on proliferation and apoptosis in the primary cultured mouse osteoblasts, which were exposed to different concentration of NaF (10−6–5 × 10−4M). We examined the effect of NaF on proliferation, cell cycle, apoptosis, oxidative stress, and the protein level of insulin-like growth factor-I (IGF-I) in osteoblasts. All the tested NaF inhibited proliferation and arrested cell cycle at S phase in osteoblasts, and further demonstrated to induce apoptosis in osteoblasts. On the other hand, we found that NaF increased oxidative stress and decreased protein expression of IGF-I. Our study herein suggested that NaF caused proliferation suppression, and apoptosis may contribute to decrease IGF-I expression and increased oxidative stress damage by NaF in the primary mouse osteoblasts.
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影响因子：
4
作者：
Ho, Wei-Pin;Chan, Wing-Pong;Chen, Ruei-Ming
通讯作者：
Chen, Ruei-Ming
影响因子：
--
作者：
Liting Sun;Fuqing Yu;Zhi-hong Xu;Xi-bo Zeng;M. Ferreri;B. Han
通讯作者：
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影响因子：
4.3
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Ling-Fei He;Jian-Gang Chen
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Jian-Gang Chen
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4.5
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DOI：
10.1016/j.bbrc.2009.08.114
发表时间：
2009-11
影响因子：
3.1
作者：
Q. Ma;Tian-lun Yang;J. Yin;Z. Peng;Min Yu;Zhaoqian Liu;Fang-Ping Chen
通讯作者：
Q. Ma;Tian-lun Yang;J. Yin;Z. Peng;Min Yu;Zhaoqian Liu;Fang-Ping Chen